Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 2/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5877452 | 1.00 | MEN1 (0.47) | MEN1KMT2AABCC1ALOX5BLM | |
| SCHEMBL5878078 | 0.93 | MEN1 (0.47) | MEN1KMT2AABCC1ALOX5BLM | |
| SCHEMBL5878075 | 0.93 | MEN1 (0.47) | MEN1KMT2AABCC1ALOX5BLM | |
| SCHEMBL5878063 | 0.89 | KDM4E (0.47) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL5878060 | 0.89 | KDM4E (0.47) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL5878248 | 0.88 | MEN1 (0.61) | MEN1KMT2AABCC1MAPTNPC1 | |
| SCHEMBL5878243 | 0.88 | MEN1 (0.61) | MEN1KMT2AABCC1MAPTNPC1 | |
| SCHEMBL7487482 | 0.85 | MEN1 (0.47) | MEN1KMT2AABCC1ALOX5BLM | |
| SCHEMBL7487486 | 0.85 | MEN1 (0.47) | MEN1KMT2AABCC1ALOX5BLM | |
| SCHEMBL5877121 | 0.83 | MEN1 (0.45) | MEN1KMT2AABCC1BLMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060706-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2006-06-13 | — | — | US | disclosed |
| EP-1216233-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023364-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |