Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.43 |
| ▸ | TUBB | P07437 | 2/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.43 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.43 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.43 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.43 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.43 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.43 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.43 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.43 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5878063 | 1.00 | KDM4E (0.47) | KDM4EMAPK1EGFRSMN1; SMN2LMNA | |
| SCHEMBL5877035 | 0.94 | TUBB4A (0.51) | KDM4EMAPK1SMN1; SMN2LMNATUBB4A | |
| SCHEMBL5877029 | 0.94 | TUBB4A (0.51) | KDM4EMAPK1SMN1; SMN2LMNATUBB4A | |
| SCHEMBL5877288 | 0.89 | KDM4E (0.59) | KDM4EMAPK1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL5877289 | 0.89 | KDM4E (0.59) | KDM4EMAPK1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL5877456 | 0.89 | MEN1 (0.47) | KDM4EMAPK1EGFRKMT2AMEN1 | |
| SCHEMBL5877452 | 0.89 | MEN1 (0.47) | KDM4EMAPK1EGFRKMT2AMEN1 | |
| SCHEMBL7539728 | 0.86 | ALDH1A1 (0.43) | KDM4EEGFRSMN1; SMN2LMNAKMT2A | |
| SCHEMBL7539725 | 0.86 | ALDH1A1 (0.43) | KDM4EEGFRSMN1; SMN2LMNAKMT2A | |
| SCHEMBL5877668 | 0.84 | KDM4E (0.47) | KDM4EMAPK1SMN1; SMN2LMNATUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060706-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2006-06-13 | — | — | US | disclosed |
| EP-1216233-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023364-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |