Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.61 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.44 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5878248 | 1.00 | MEN1 (0.61) | MEN1KMT2AABCC1MAPTKDM4E | |
| SCHEMBL5877289 | 0.91 | KDM4E (0.59) | MEN1KMT2AMAPTKDM4EMAPK1 | |
| SCHEMBL5877288 | 0.91 | KDM4E (0.59) | MEN1KMT2AMAPTKDM4EMAPK1 | |
| SCHEMBL7487486 | 0.89 | MEN1 (0.47) | MEN1KMT2AABCC1MAPTKDM4E | |
| SCHEMBL7487482 | 0.89 | MEN1 (0.47) | MEN1KMT2AABCC1MAPTKDM4E | |
| SCHEMBL5877452 | 0.88 | MEN1 (0.47) | MEN1KMT2AABCC1MAPTKDM4E | |
| SCHEMBL5877456 | 0.88 | MEN1 (0.47) | MEN1KMT2AABCC1MAPTKDM4E | |
| SCHEMBL5878075 | 0.88 | MEN1 (0.47) | MEN1KMT2AABCC1MAPTKDM4E | |
| SCHEMBL5878078 | 0.88 | MEN1 (0.47) | MEN1KMT2AABCC1MAPTKDM4E | |
| SCHEMBL5877121 | 0.86 | MEN1 (0.45) | MEN1KMT2AABCC1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060706-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2006-06-13 | — | — | US | disclosed |
| EP-1216233-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023364-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |