Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.54 |
| ▸ | MEN1 | O00255 | 6/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.47 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RAD1 | O60671 | 1/20 | 0.47 |
| ▸ | CFTR | P13569 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | CASP6 | P55212 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5877288 | 1.00 | KDM4E (0.59) | KDM4EMAPK1LMNASMN1; SMN2KMT2A | |
| SCHEMBL5878243 | 0.91 | MEN1 (0.61) | KDM4EMAPK1LMNASMN1; SMN2KMT2A | |
| SCHEMBL5878248 | 0.91 | MEN1 (0.61) | KDM4EMAPK1LMNASMN1; SMN2KMT2A | |
| SCHEMBL5878060 | 0.89 | KDM4E (0.47) | KDM4EMAPK1LMNASMN1; SMN2KMT2A | |
| SCHEMBL5878063 | 0.89 | KDM4E (0.47) | KDM4EMAPK1LMNASMN1; SMN2KMT2A | |
| SCHEMBL5877665 | 0.88 | KDM4E (0.47) | KDM4EMAPK1LMNASMN1; SMN2KMT2A | |
| SCHEMBL5877668 | 0.88 | KDM4E (0.47) | KDM4EMAPK1LMNASMN1; SMN2KMT2A | |
| SCHEMBL5877035 | 0.88 | TUBB4A (0.51) | KDM4EMAPK1LMNASMN1; SMN2KMT2A | |
| SCHEMBL5877029 | 0.88 | TUBB4A (0.51) | KDM4EMAPK1LMNASMN1; SMN2KMT2A | |
| SCHEMBL5877397 | 0.86 | MEN1 (0.50) | KDM4EMAPK1LMNASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060706-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2006-06-13 | — | — | US | disclosed |
| EP-1216233-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023364-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |