SCHEMBL5878378

SCHEMBL5878378

O=C1C2CC=CCC2C(=O)N1CCO

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.50
ATM Q13315 1/20 0.50
CA1 P00915 2/20 0.47
CA2 P00918 2/20 0.47
CA9 Q16790 2/20 0.47
CA4 P22748 1/20 0.47
TP53 P04637 3/20 0.46
TDP1 Q9NUW8 2/20 0.46
KMT2A Q03164 3/20 0.44
LMNA P02545 2/20 0.44
HPGD P15428 2/20 0.44
CYP3A4 P08684 1/20 0.44
ALOX15 P16050 1/20 0.44
TSHR P16473 1/20 0.44
MAPK1 P28482 1/20 0.44
HTT P42858 1/20 0.44
HIF1A Q16665 1/20 0.44
HSD17B10 Q99714 1/20 0.44
KDM4E B2RXH2 1/20 0.43
CA12 O43570 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9181566 0.88 HTT (0.54) ALDH1A1ATMCA1CA2CA9
SCHEMBL9181557 0.88 HTT (0.54) ALDH1A1ATMCA1CA2CA9
SCHEMBL17532418 0.87 ALDH1A1 (0.57) ALDH1A1ATMCA1CA2CA9
SCHEMBL8620015 0.83 ALDH1A1 (0.53) ALDH1A1ATMCA1CA2CA9
SCHEMBL21168596 0.81 ALDH1A1 (0.61) ALDH1A1ATMCA1CA2CA9
SCHEMBL16039625 0.80 USP2 (0.44) ALDH1A1TDP1KMT2ALMNAHPGD
SCHEMBL14344404 0.77 HTT (0.44) ALDH1A1ATMCA1CA2CA9
SCHEMBL1147309 0.77 ALDH1A1 (0.47) ALDH1A1ATMTP53KMT2ALMNA
SCHEMBL9179747 0.76 ALDH1A1 (0.47) ALDH1A1ATMCA1CA2CA9
SCHEMBL9179752 0.76 ALDH1A1 (0.47) ALDH1A1ATMCA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11990339-B2 Semiconductor device and method of manufacture TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY, LTD. (TW) 2024-05-21 US claimed
US-20210366704-A1 Semiconductor Device and Method of Manufacture TAIWAN SEMICONDUCTOR MFG CO LTD (TW) 2021-11-25 US claimed
US-11081350-B2 Semiconductor device and method of manufacture TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY, LTD. (TW) 2021-08-03 US claimed
US-10867803-B2 Semiconductor device and method TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY, LTD. (TW) 2020-12-15 US claimed
US-20200083038-A1 Semiconductor Device and Method of Manufacture TAIWAN SEMICONDUCTOR MFG CO LTD (TW) 2020-03-12 US claimed
US-10483108-B2 Semiconductor device and method of manufacture TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY, LTD. (TW) 2019-11-19 US claimed
US-20190279876-A1 Semiconductor Device and Method TAIWAN SEMICONDUCTOR MFG CO LTD (TW) 2019-09-12 US claimed
US-10312106-B2 Semiconductor device and method TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY, LTD. (TW) 2019-06-04 US claimed
US-20190035637-A1 Semiconductor Device and Method TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY, LTD. (TW) 2019-01-31 US claimed
US-20180315595-A1 Semiconductor Device and Method of Manufacture TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY, LTD. (TW) 2018-11-01 US claimed
US-20240282575-A1 SEMICONDUCTOR DEVICE AND METHOD OF MANUFACTURE TAIWAN SEMICONDUCTOR MFG CO LTD (TW) 2024-08-22 US disclosed
US-11990339-B2 Semiconductor device and method of manufacture TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY, LTD. (TW) 2024-05-21 US disclosed
CN-114349930-B Aqueous polyurethane resin emulsion and preparation method thereof, and earphone sleeve leather 万华化学集团股份有限公司 2023-07-04 CN disclosed
CN-114349930-A Waterborne polyurethane resin emulsion, preparation method and earphone cover leather 万华化学集团股份有限公司 2022-04-15 CN disclosed
US-20210366704-A1 Semiconductor Device and Method of Manufacture TAIWAN SEMICONDUCTOR MFG CO LTD (TW) 2021-11-25 US disclosed
EP-0946569-B1 CYCLOALIPHATIC EPOXY COMPOUNDS LONZA SPA (IT) 2003-08-20 EP disclosed
US-20030100555-A1 Prodrugs of a 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives SUGEN. INC. 2003-05-29 US disclosed
US-6080872-A A MONOMER FOR PRODUCING A CURED EPOXY RESIN COMPOSITIONS EXHIBITING SUPERIOR MECHANICAL PROPERTIES, TENSILE AND FLEXURAL STRENGTH AND TOUGHNESS LONZA S.P.A. (IT) 2000-06-27 US disclosed
EP-0946569-A2 CYCLOALIPHATIC EPOXY COMPOUNDS LONZA S.P.A. (IT) 1999-10-06 EP disclosed
WO-1998027099-A2 CYCLOALIPHATIC EPOXY COMPOUNDS LONZA S.P.A. (IT) 1998-06-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030100555-A1 Prodrugs of a 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives PLK2, CDK2, PDPK1 ALDH1A1 1738/4885ATM 557/4885CA1 4077/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.