Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PREP | P48147 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL586528 | 0.90 | TMEM97 (0.46) | TMEM97SIGMAR1ALDH1A1NPC1RAB9A | |
| SCHEMBL587386 | 0.85 | PKM (0.48) | NPC1RAB9APKMNPSR1PREP | |
| SCHEMBL587226 | 0.82 | POLB (0.39) | ALDH1A1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL15878549 | 0.75 | SMN1; SMN2 (0.60) | NPC1RAB9APREPSMN1; SMN2 | |
| SCHEMBL13103714 | 0.74 | ALDH1A1 (0.35) | ALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL586922 | 0.73 | ALDH1A1 (0.49) | TMEM97SIGMAR1ALDH1A1NPC1RAB9A | |
| SCHEMBL615936 | 0.72 | CYP3A4 (0.45) | ALDH1A1NPC1RAB9APKMNPSR1 | |
| SCHEMBL13246605 | 0.72 | TMEM97 (0.49) | TMEM97SIGMAR1NPC1RAB9ANPSR1 | |
| SCHEMBL672317 | 0.72 | TMEM97 (0.49) | TMEM97SIGMAR1NPC1RAB9ANPSR1 | |
| SCHEMBL4521587 | 0.72 | TMEM97 (0.49) | TMEM97SIGMAR1NPC1RAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417131-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117323-A1 | METHOD AND APPARATUS FOR PRODUCING HEAT ENERGY AND CARBON DIOXIDE | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | WO | disclosed |