Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.40 |
| ▸ | TGM2 | P21980 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | F13A1 | P00488 | 1/20 | 0.37 |
| ▸ | TGM1 | P22735 | 1/20 | 0.37 |
| ▸ | TGM3 | Q08188 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13946462 | 0.86 | FFAR2 (0.52) | CYP2C19KMT2ACYP1A2FFAR2LMNA | |
| SCHEMBL4264360 | 0.84 | CYP2C19 (0.50) | CYP2C19KMT2AFFAR2TGM2LMNA | |
| SCHEMBL6002239 | 0.84 | CYP2C19 (0.50) | CYP2C19KMT2AFFAR2TGM2LMNA | |
| SCHEMBL6423644 | 0.84 | CYP2C19 (0.73) | CYP2C19FFAR2LMNASMN1; SMN2 | |
| SCHEMBL6423647 | 0.84 | CYP2C19 (0.73) | CYP2C19FFAR2LMNASMN1; SMN2 | |
| SCHEMBL5879152 | 0.84 | CYP2C19 (0.73) | CYP2C19KMT2ACYP1A2FFAR2TGM2 | |
| SCHEMBL7268439 | 0.81 | CYP2C19 (0.50) | CYP2C19KMT2ACYP1A2LMNASMN1; SMN2 | |
| SCHEMBL623726 | 0.78 | SLC6A2 (0.44) | CYP2C19CYP1A2FFAR2LMNASMN1; SMN2 | |
| SCHEMBL5879182 | 0.78 | SLC6A2 (0.44) | CYP2C19CYP1A2FFAR2LMNASMN1; SMN2 | |
| SCHEMBL5879184 | 0.78 | SLC6A2 (0.44) | CYP2C19CYP1A2FFAR2LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7034056-B2 | Aryl and biaryl compounds having MCH modulatory activity | PHARMACOPEIA DRUG DISCOVERY, INC. (US) | 2006-04-25 | — | — | US | disclosed |
| EP-1370520-A1 | ARYL AND BIARYL COMPOUNDS HAVING MCH MODULATORY ACTIVITY | PHARMACOPEIA, INC. (US) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002076929-A1 | ARYL AND BIARYL COMPOUNDS HAVING MCH MODULATORY ACTIVITY | PHARMACOPEIA, INC. (US) | 2002-10-03 | — | — | WO | disclosed |