SCHEMBL6423644

SCHEMBL6423644

C=CC[C@H](C(=O)Cl)c1ccccc1

nearest known ligand 0.73

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 1/20 0.73
SMN1; SMN2 Q16637 3/20 0.41
EPHX1 P07099 1/20 0.41
LMNA P02545 4/20 0.39
ALDH1A1 P00352 3/20 0.39
KDM4E B2RXH2 2/20 0.39
MAPT P10636 2/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
NPSR1 Q6W5P4 1/20 0.39
FFAR2 O15552 1/20 0.38
CYP2D6 P10635 1/20 0.38
SRC P12931 1/20 0.38
HSD17B10 Q99714 2/20 0.37
ALOX15 P16050 1/20 0.37
TSHR P16473 1/20 0.37
MAPK1 P28482 1/20 0.36
KCNQ2 O43526 1/20 0.36
ATM Q13315 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6423647 1.00 CYP2C19 (0.73) CYP2C19SMN1; SMN2EPHX1LMNAALDH1A1
SCHEMBL5371218 0.85 CYP2C19 (0.79) CYP2C19SMN1; SMN2EPHX1LMNAALDH1A1
SCHEMBL1458050 0.85 CYP2C19 (1.00) CYP2C19SMN1; SMN2EPHX1LMNAALDH1A1
SCHEMBL1458057 0.85 CYP2C19 (1.00) CYP2C19SMN1; SMN2EPHX1LMNAALDH1A1
SCHEMBL666893 0.85 CYP2C19 (1.00) CYP2C19SMN1; SMN2EPHX1LMNAALDH1A1
SCHEMBL13946462 0.84 FFAR2 (0.52) CYP2C19LMNAL3MBTL1FFAR2CYP2D6
SCHEMBL5879290 0.84 CYP2C19 (0.51) CYP2C19SMN1; SMN2LMNAFFAR2
SCHEMBL1458161 0.83 CYP2C19 (0.96) CYP2C19SMN1; SMN2EPHX1LMNAALDH1A1
SCHEMBL6967261 0.83 CYP2C19 (0.76) CYP2C19SMN1; SMN2EPHX1LMNAALDH1A1
SCHEMBL1457969 0.83 CYP2C19 (0.96) CYP2C19SMN1; SMN2EPHX1LMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1077942-B1 CARBOXY SUBSTITUTED CARBOXAMIDE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS AVENTIS PHARMA INC (US) 2005-01-12 EP disclosed
US-6316445-B1 TACHYKININ RECEPTOR ANTAGONISTS AVENTIS PHARMACEUTICALS INC. 2001-11-13 US disclosed
EP-1077942-A1 CARBOXY SUBSTITUTED CARBOXAMIDE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS Aventis Pharmaceuticals Inc. (US) 2001-02-28 EP disclosed
WO-1999059972-A1 CARBOXY SUBSTITUTED CARBOXAMIDE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS AVENTIS PHARMACEUTICALS INC. (US) 1999-11-25 WO disclosed
US-5932571-A Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases HOECHST MARION ROUSSEL, INC. (US) 1999-08-03 US disclosed