Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.75 |
| ▸ | HTT | P42858 | 1/20 | 0.75 |
| ▸ | GAA | P10253 | 2/20 | 0.69 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.67 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.67 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.67 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.67 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.67 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.67 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.67 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.67 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | KDM1A | O60341 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3061430 | 0.86 | MAPT (1.00) | MAPTHTTGAAHDAC3HDAC4 | |
| SCHEMBL10198474 | 0.85 | MAPT (0.77) | MAPTHTTGAAHDAC3HDAC4 | |
| SCHEMBL18421284 | 0.85 | MAPT (0.77) | MAPTHTTGAAHDAC3HDAC4 | |
| Hydrochloric Acid SCHEMBL27689202 | 0.84 | MAPT (0.96) | MAPTHTTGAAHDAC3HDAC4 | |
| SCHEMBL11705109 | 0.83 | TRPV1 (0.82) | MAPTHTTGAAHDAC3HDAC4 | |
| SCHEMBL27671467 | 0.83 | MAPT (0.86) | MAPTHTTGAAHDAC3HDAC4 | |
| SCHEMBL27507480 | 0.83 | EPHX2 (0.73) | MAPTGAAHDAC3HDAC4HDAC1 | |
| SCHEMBL13356363 | 0.83 | MAPT (0.80) | MAPTHTTGAAHDAC3HDAC4 | |
| Methyl Alcohol SCHEMBL4593446 | 0.83 | MAPT (0.93) | MAPTHTTGAAHDAC3HDAC4 | |
| SCHEMBL2003074 | 0.82 | MAPT (0.77) | MAPTHTTGAAHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101273016-B | Antibacterial quinoline derivatives | JANSSEN PHARMACEUTICA NV | 2013-01-02 | — | — | CN | disclosed |
| CN-101252928-B | Quinoline derivatives as antibacterial agents | JANSSEN PHARMACEUTICA NV | 2012-05-23 | — | — | CN | disclosed |
| CN-101273016-A | Antibacterial quinoline derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2008-09-24 | — | — | CN | disclosed |
| CN-101252928-A | Quinoline derivatives as antibacterial agents | JANSSEN PHARMACEUTICA NV (BE) | 2008-08-27 | — | — | CN | disclosed |
| US-7105508-B1 | Integrin receptors antagonists | ABBOTT GMBH & CO. KG (DE) | 2006-09-12 | — | — | US | disclosed |
| EP-1202988-A2 | NOVEL INTEGRIN RECEPTOR ANTAGONISTS | BASF AKTIENGESELLSCHAFT (DE) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001010847-A2 | NOVEL INTEGRIN RECEPTOR ANTAGONISTS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-15 | — | — | WO | disclosed |