Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 8/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | HTT | P42858 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | EYA2 | O00167 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | SGK1 | O00141 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5879919 | 1.00 | LMNA (0.45) | LMNACYP3A4CYP2C9XBP1MAPT | |
| SCHEMBL5879602 | 0.93 | MAPT (0.49) | LMNAMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL5879603 | 0.93 | MAPT (0.49) | LMNAMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL5879907 | 0.88 | LMNA (0.51) | LMNACYP3A4CYP2C9MAPTALDH1A1 | |
| SCHEMBL5879910 | 0.88 | LMNA (0.51) | LMNACYP3A4CYP2C9MAPTALDH1A1 | |
| SCHEMBL5880285 | 0.87 | LMNA (0.49) | LMNACYP2C9MAPTALDH1A1KMT2A | |
| SCHEMBL5880282 | 0.87 | LMNA (0.49) | LMNACYP2C9MAPTALDH1A1KMT2A | |
| SCHEMBL5879904 | 0.87 | KMT2A (0.52) | LMNACYP3A4CYP2C9MAPTALDH1A1 | |
| SCHEMBL5879902 | 0.87 | KMT2A (0.52) | LMNACYP3A4CYP2C9MAPTALDH1A1 | |
| SCHEMBL5880151 | 0.87 | LMNA (0.47) | LMNACYP3A4CYP2C9MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7026339-B2 | Inhibitors of HCV NS5B polymerase | PFIZER INC. | 2006-04-11 | — | — | US | disclosed |