Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SPR | P35270 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4137212 | 0.82 | KDM4E (0.48) | MAPK1KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL11082225 | 0.80 | NPC1 (0.35) | KDM4EALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL10209172 | 0.80 | CHRM3 (0.40) | MAPK1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL5880232 | 0.78 | ALOX15 (0.44) | KDM4EALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL10224440 | 0.76 | ENPP2 (0.41) | MAPK1KDM4EALDH1A1HSD17B10KMT2A | |
| SCHEMBL5053548 | 0.75 | KDM4E (0.46) | MAPK1KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL11081705 | 0.75 | CYP1A2 (0.41) | MAPK1KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL10209168 | 0.72 | SLC6A15 (0.41) | KDM4EALDH1A1RAB9AKMT2AMAPT | |
| SCHEMBL68869 | 0.72 | MAPK1 (0.63) | MAPK1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL13350435 | 0.72 | PTGER4 (0.47) | MAPK1KDM4EALDH1A1HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2006516628-A | — | — | 2006-07-06 | — | — | JP | claimed |
| EP-1587796-A1 | SATURATED QUINOXALINE DERIVATIVES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR LIGANDS | AstraZeneca AB (SE) | 2005-10-26 | — | — | EP | claimed |
| US-20050004130-A1 | New metabotropic glutamate receptor compounds | ASTRAZENECA AND NPS PHARMACEUTICALS, INC. | 2005-01-06 | — | — | US | claimed |
| WO-2004069813-A1 | SATURATED QUINOXALINE DERIVATIVES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR LIGANDS | ASTRAZENECA AB (SE) | 2004-08-19 | — | — | WO | claimed |
| EP-1587796-A1 | SATURATED QUINOXALINE DERIVATIVES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR LIGANDS | AstraZeneca AB (SE) | 2005-10-26 | — | — | EP | disclosed |
| US-20050004130-A1 | New metabotropic glutamate receptor compounds | ASTRAZENECA AND NPS PHARMACEUTICALS, INC. | 2005-01-06 | — | — | US | disclosed |
| WO-2004069813-A1 | SATURATED QUINOXALINE DERIVATIVES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR LIGANDS | ASTRAZENECA AB (SE) | 2004-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004130-A1 | New metabotropic glutamate receptor compounds | GRM1, GRIN1, GRM2 | MAPK1 1457/4885KDM4E 3065/4885ALDH1A1 2539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.