SCHEMBL588119

SCHEMBL588119

Cc1c(C2CCCCC2)nc(F)c(F)c1C(=O)O

nearest known ligand 0.42

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 1/20 0.42
TAS1R3 Q7RTX0 4/20 0.39
TAS1R1 Q7RTX1 3/20 0.39
TAS1R2 Q8TE23 3/20 0.39
KMO O15229 2/20 0.33
KDM4E B2RXH2 1/20 0.33
GLA P06280 1/20 0.33
HTT P42858 1/20 0.33
KMT2A Q03164 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
HIF1A Q16665 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
KDM5B Q9UGL1 1/20 0.31
HCAR2 Q8TDS4 1/20 0.31
ABCC1 P33527 1/20 0.31
PTGS2 P35354 1/20 0.30
SCN10A Q9Y5Y9 1/20 0.30
S1PR1 P21453 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL588118 0.80 DHODH (0.39) DHODHTAS1R3TAS1R1TAS1R2KMO
SCHEMBL15170484 0.69 HRH2 (0.35) KDM4ETDP1L3MBTL1PTGS2
SCHEMBL18781916 0.69 KMO (0.37) DHODHTAS1R3TAS1R1TAS1R2KMO
SCHEMBL1711661 0.68 KDM4E (0.51) DHODHKMOKDM4EGLAHTT
SCHEMBL17323560 0.67 DHODH (0.36) DHODHTAS1R3TAS1R1TAS1R2KMO
SCHEMBL24890374 0.67 KDM4E (0.35) KDM4EGLAHTTKMT2ASMN1; SMN2
SCHEMBL15022565 0.66 HCAR2 (0.35) DHODHKDM4EHTTKMT2ASMN1; SMN2
SCHEMBL28192754 0.66 HCAR2 (0.35) DHODHKDM4EKMT2ASMN1; SMN2HCAR2
SCHEMBL15414517 0.64 KMO (0.33) DHODHKMOKDM4EGLAHTT
SCHEMBL28429040 0.64 KMO (0.33) DHODHKMOKDM4EGLAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2417131-A1 ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS AstraZeneca AB (SE) 2012-02-15 EP disclosed
WO-2010117323-A1 METHOD AND APPARATUS FOR PRODUCING HEAT ENERGY AND CARBON DIOXIDE ASTRAZENECA AB (SE) 2010-10-14 WO disclosed