Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 4/20 | 0.59 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.39 |
| ▸ | FEN1 | P39748 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | BCL6 | P41182 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28189689 | 0.81 | NUDT1 (0.61) | NUDT1HRH4ALOX5APFEN1HSP90AA1 | |
| SCHEMBL11036646 | 0.79 | NUDT1 (0.65) | NUDT1HRH4HRH3ALDH1A1NPC1 | |
| SCHEMBL11212136 | 0.78 | NUDT1 (0.57) | NUDT1HRH4ALOX5APFEN1HSP90AA1 | |
| SCHEMBL2597642 | 0.77 | NUDT1 (0.35) | NUDT1 | |
| SCHEMBL18072508 | 0.76 | NUDT1 (0.61) | NUDT1HRH4HRH3NPC1RAB9A | |
| SCHEMBL31403790 | 0.76 | NUDT1 (0.57) | NUDT1HRH4ALOX5APFEN1HSP90AA1 | |
| SCHEMBL24441073 | 0.75 | NUDT1 (0.54) | NUDT1HRH4ALOX5APFEN1HSP90AA1 | |
| SCHEMBL29154 | 0.75 | NUDT1 (0.69) | NUDT1HRH4ALOX5APFEN1HSP90AA1 | |
| SCHEMBL31201109 | 0.75 | NUDT1 (0.59) | NUDT1HRH4HRH3 | |
| SCHEMBL18072493 | 0.75 | NUDT1 (1.00) | NUDT1HRH4HSP90AA1AURKAPRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001910-B1 | Thiazolidinedione derivatives as antidiabetic agents | VITA-INVEST S.A. (ES) | 2006-02-21 | — | — | US | disclosed |
| EP-1231211-B1 | THIAZOLIDINEDIONE DERIVATIVES AS ANTIDIABETIC AGENTS | VITA INVEST SA (ES) | 2003-05-28 | — | — | EP | disclosed |
| EP-1231211-A1 | THIAZOLIDINEDIONE DERIVATIVES AS ANTIDIABETIC AGENTS | VITA-INVEST, S.A. (ES) | 2002-08-14 | — | — | EP | disclosed |