Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL182862 | 0.80 | PLK1 (0.49) | HPGDALDH1A1TP53GLAMAPT | |
| SCHEMBL182737 | 0.76 | KDM4E (0.44) | HPGDALDH1A1POLBKDM4EMAPT | |
| SCHEMBL7355446 | 0.76 | HTT (0.46) | HPGDALDH1A1KDM4EMAPTHSD17B10 | |
| SCHEMBL5885171 | 0.75 | ALDH1A1 (0.44) | HPGDALDH1A1TP53KDM4EHSD17B10 | |
| SCHEMBL6320988 | 0.74 | KMT2A (0.48) | HPGDPOLBTP53GLAKMT2A | |
| SCHEMBL182820 | 0.74 | ALDH1A1 (0.49) | HPGDALDH1A1POLBKDM4EMAPT | |
| SCHEMBL13733997 | 0.73 | ALDH1A1 (0.58) | ADORA2AHPGDALDH1A1POLBSMPD1 | |
| SCHEMBL11946685 | 0.73 | TAS1R3 (0.57) | ADORA2AHPGDALDH1A1TP53GLA | |
| SCHEMBL182690 | 0.73 | MKNK1 (0.40) | ADORA2AHPGDALDH1A1POLBGLA | |
| SCHEMBL3034809 | 0.72 | HPGD (0.49) | HPGDALDH1A1POLBHSD17B10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115617-B2 | Amino-substituted pyrimidinyl derivatives and methods of use | AMGEN INC. (US) | 2006-10-03 | — | — | US | disclosed |
| US-6939874-B2 | Substituted pyrimidinyl derivatives and methods of use | AMGEN INC. (US) | 2005-09-06 | — | — | US | disclosed |
| EP-1427421-A1 | 2,4-DISUBSTITUTED PYRIMIDINYL DERIVATIVES FOR USE AS ANTICANCER AGENTS | Amgen Inc. (US) | 2004-06-16 | — | — | EP | disclosed |
| WO-2003018021-A1 | 2,4-DISUBSTITUTED PYRIMIDINYL DERIVATIVES FOR USE AS ANTICANCER AGENTS | AMGEN INC. (US) | 2003-03-06 | — | — | WO | disclosed |