Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GALR3 | O60755 | 3/20 | 0.37 |
| ▸ | NR2F2 | P24468 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14800502 | 0.82 | KDM4E (0.51) | KMT2ALMNATNFPKMHTT | |
| SCHEMBL699050 | 0.81 | RAB9A (0.39) | KMT2ALMNATNFPKMHTT | |
| SCHEMBL693236 | 0.77 | CSNK1E (0.41) | KMT2ALMNATNFHTTTSHR | |
| SCHEMBL1520226 | 0.77 | KMT2A (0.62) | KMT2ALMNATNFPKMHTT | |
| SCHEMBL315552 | 0.76 | KDM4E (0.46) | KMT2ALMNAHTTTP53KDM4E | |
| SCHEMBL3610430 | 0.76 | CNR2 (0.46) | LMNATNFGALR3NR2F2RAB9A | |
| SCHEMBL12082609 | 0.74 | KMT2A (0.72) | KMT2AHTTTSHRKDM4ERAB9A | |
| SCHEMBL9691244 | 0.73 | KMT2A (0.57) | KMT2ALMNATP53KDM4ERAB9A | |
| SCHEMBL3483348 | 0.73 | ALDH1A1 (0.43) | KMT2ALMNAPKMHTTTSHR | |
| SCHEMBL7260548 | 0.72 | KMT2A (1.00) | KMT2AHTTKDM4EGALR3NR2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115617-B2 | Amino-substituted pyrimidinyl derivatives and methods of use | AMGEN INC. (US) | 2006-10-03 | — | — | US | disclosed |
| US-6939874-B2 | Substituted pyrimidinyl derivatives and methods of use | AMGEN INC. (US) | 2005-09-06 | — | — | US | disclosed |
| EP-1427421-A1 | 2,4-DISUBSTITUTED PYRIMIDINYL DERIVATIVES FOR USE AS ANTICANCER AGENTS | Amgen Inc. (US) | 2004-06-16 | — | — | EP | disclosed |
| WO-2003018021-A1 | 2,4-DISUBSTITUTED PYRIMIDINYL DERIVATIVES FOR USE AS ANTICANCER AGENTS | AMGEN INC. (US) | 2003-03-06 | — | — | WO | disclosed |