Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dopexamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 4/20 | 0.86 |
| ▸ | DRD3 | P35462 | 4/20 | 0.86 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.86 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.86 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.86 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.86 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.86 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.86 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.86 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.86 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.86 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.86 |
| ▸ | HRH1 | P35367 | 1/20 | 0.86 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.86 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.86 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.86 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.86 |
| ▸ | DRD2 | P14416 | 3/20 | 0.58 |
| ▸ | DRD4 | P21917 | 3/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dopexamine SCHEMBL5605569 | 0.93 | ADRB2 (1.00) | DRD1DRD3ADRB2SLC6A2SLC6A3 | |
| Dopexamine SCHEMBL29711811 | 0.93 | ADRB2 (1.00) | DRD1DRD3ADRB2SLC6A2SLC6A3 | |
| SCHEMBL7278498 | 0.93 | ADRB2 (1.00) | DRD1DRD3ADRB2SLC6A2SLC6A3 | |
| SCHEMBL7272201 | 0.93 | ADRB2 (1.00) | DRD1DRD3ADRB2SLC6A2SLC6A3 | |
| Dopexamine SCHEMBL122233 | 0.93 | ADRB2 (1.00) | DRD1DRD3ADRB2SLC6A2SLC6A3 | |
| Dopexamine SCHEMBL123114 | 0.91 | ADRB2 (0.97) | DRD1DRD3ADRB2SLC6A2SLC6A3 | |
| Dopexamine SCHEMBL29390436 | 0.91 | ADRB2 (0.97) | DRD1DRD3ADRB2SLC6A2SLC6A3 | |
| Bromide SCHEMBL7280381 | 0.91 | ADRB2 (0.97) | DRD1DRD3ADRB2SLC6A2SLC6A3 | |
| Dopexamine SCHEMBL5464371 | 0.91 | ADRB2 (0.97) | DRD1DRD3ADRB2SLC6A2SLC6A3 | |
| Dopexamine SCHEMBL123115 | 0.91 | ADRB2 (0.97) | DRD1DRD3ADRB2SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7026360-B1 | Pharmaceutical compositions containing compounds with activity for the enhancement of absorption of active ingredients | INPHARMA S.A. (CH) | 2006-04-11 | — | — | US | disclosed |