Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.57 |
| ▸ | MTOR | P42345 | 12/20 | 0.57 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.48 |
| ▸ | PIK3R1 | P27986 | 7/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.42 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.42 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.42 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7999520 | 0.77 | PIK3CA (0.61) | PIK3CAMTORPIK3CBPIK3R1PIK3CD | |
| SCHEMBL27539841 | 0.75 | PIK3CA (0.54) | PIK3CAMTORPIK3CBPIK3R1KDM4E | |
| SCHEMBL8008565 | 0.72 | PIK3CA (1.00) | PIK3CAMTORPIK3CBPIK3R1PIK3CD | |
| SCHEMBL8009816 | 0.72 | PIK3CA (0.73) | PIK3CAMTORPIK3CBPIK3R1PIK3CD | |
| SCHEMBL11764095 | 0.70 | GAA (0.41) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL7999531 | 0.69 | PIK3CA (0.72) | PIK3CAMTORPIK3CBPIK3R1PIK3CD | |
| SCHEMBL27657223 | 0.69 | MAPKAPK2 (0.45) | ALDH1A1HTT | |
| SCHEMBL8003220 | 0.69 | PIK3CA (0.78) | PIK3CAMTORPIK3CBPIK3R1PIK3CD | |
| SCHEMBL4018233 | 0.69 | PIK3CA (0.65) | PIK3CAMTORPIK3CBPIK3R1LMNA | |
| SCHEMBL1310963 | 0.68 | PIK3CA (0.51) | PIK3CAMTORPIK3CBPIK3R1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071189-B2 | Heterocyclic compound and antitumor agent containing the same as active ingredient | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 2006-07-04 | — | — | US | disclosed |
| US-20040116421-A1 | Heterocyclic compound and antitumor agent containing the same as active ingredient | OHARA PHARMACEUTICAL CO., LTD. (JP) | 2004-06-17 | — | — | US | disclosed |