Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 9/20 | 0.65 |
| ▸ | MTOR | P42345 | 8/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4018669 | 0.83 | PIK3CA (0.58) | PIK3CAMTORMAPTL3MBTL1LMNA | |
| SCHEMBL20154101 | 0.81 | PIK3CA (0.53) | PIK3CAMTORLMNAHTTPIK3R1 | |
| SCHEMBL4020573 | 0.81 | MAPT (0.45) | PIK3CAMTORMAPTL3MBTL1LMNA | |
| SCHEMBL8012871 | 0.81 | PIK3CA (0.79) | PIK3CAMTORLMNAPIK3R1PIK3CB | |
| SCHEMBL8008565 | 0.79 | PIK3CA (1.00) | PIK3CAMTORPIK3R1PIK3CBPIK3CD | |
| SCHEMBL1308905 | 0.78 | MAPT (0.61) | PIK3CAMTORMAPTL3MBTL1LMNA | |
| SCHEMBL1311534 | 0.78 | PIK3CA (0.61) | PIK3CAMTORPIK3R1PIK3CBPIK3CD | |
| SCHEMBL32854 | 0.76 | MTOR (0.76) | PIK3CAMTORPIK3CG | |
| SCHEMBL4018631 | 0.75 | PIK3CA (1.00) | PIK3CAMTORPIK3R1PIK3CBPIK3CD | |
| SCHEMBL38827 | 0.75 | MAPT (0.57) | PIK3CAMTORMAPTL3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009093981-A1 | TRIAZINE COMPOUNDS AS KINASE INHIBITORS | S BIO PTE LTD (SG) | 2009-07-30 | — | — | WO | disclosed |
| WO-2009093981-A1 | TRIAZINE COMPOUNDS AS KINASE INHIBITORS | S BIO PTE LTD (SG) | 2009-07-30 | — | — | WO | disclosed |