Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 6/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.39 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5887108 | 0.86 | ALKBH3 (0.43) | AHRCRHR1ALKBH3TP53HSD11B1 | |
| SCHEMBL5887235 | 0.71 | ALKBH3 (0.36) | AHRCRHR1ALKBH3TP53HSD11B1 | |
| SCHEMBL4447113 | 0.69 | AHR (0.65) | AHRTP53HSD11B1KDM4ENPC1 | |
| SCHEMBL5887035 | 0.69 | ALKBH3 (0.43) | AHRALKBH3CYP1B1PSEN1PSEN2 | |
| SCHEMBL5887503 | 0.65 | ALKBH3 (0.40) | AHRALKBH3 | |
| SCHEMBL29456490 | 0.65 | AHR (0.69) | AHRTP53HSD11B1KDM4ENPC1 | |
| SCHEMBL5886968 | 0.62 | ALKBH3 (0.39) | AHRALKBH3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2463985 | 0.62 | AHR (0.53) | AHRTP53HSD11B1KDM4ENPC1 | |
| SCHEMBL5886940 | 0.61 | RAD51 (0.40) | AHRALKBH3SMN1; SMN2CYP1B1 | |
| SCHEMBL1045006 | 0.61 | AHR (0.57) | AHRTP53HSD11B1HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037931-B2 | Corticotropin releasing factor moderator; analgesics; drug abruse, drug dependency; schizophrenia | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-05-02 | — | — | US | disclosed |
| US-20050020565-A1 | Pyrazole compound; gastrointestinal disorders; central nervous system disorders | JONES TODD K (US) | 2005-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020565-A1 | Pyrazole compound; gastrointestinal disorders; central nervous system disorders | CCKAR, CCKBR, NPY1R | AHR 16/4885CRHR1 10/4885ALKBH3 3753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.