Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.58 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.57 |
| ▸ | CTSB | P07858 | 2/20 | 0.56 |
| ▸ | TACR1 | P25103 | 2/20 | 0.51 |
| ▸ | F2 | P00734 | 1/20 | 0.51 |
| ▸ | PLAU | P00749 | 1/20 | 0.51 |
| ▸ | PLAT | P00750 | 1/20 | 0.51 |
| ▸ | CTSL | P07711 | 2/20 | 0.50 |
| ▸ | SPPL2A | Q8TCT8 | 1/20 | 0.50 |
| ▸ | CTSS | P25774 | 1/20 | 0.50 |
| ▸ | CTSK | P43235 | 1/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7320613 | 1.00 | TRPM8 (0.58) | TRPM8CTRB1CTSBTACR1F2 | |
| SCHEMBL6812568 | 0.87 | TRPM8 (0.60) | TRPM8CTRB1CTSBTACR1F2 | |
| SCHEMBL6347062 | 0.87 | TRPM8 (0.60) | TRPM8CTRB1CTSBTACR1F2 | |
| SCHEMBL8536562 | 0.87 | TRPM8 (0.60) | TRPM8CTRB1CTSBTACR1F2 | |
| SCHEMBL6810019 | 0.87 | TRPM8 (0.60) | TRPM8CTRB1CTSBTACR1F2 | |
| SCHEMBL8536514 | 0.87 | TRPM8 (0.60) | TRPM8CTRB1CTSBTACR1F2 | |
| SCHEMBL3023446 | 0.86 | TRPM8 (0.58) | TRPM8CTRB1CTSBTACR1F2 | |
| SCHEMBL6330557 | 0.86 | TRPM8 (0.58) | TRPM8CTRB1CTSBTACR1F2 | |
| SCHEMBL3023447 | 0.86 | TRPM8 (0.58) | TRPM8CTRB1CTSBTACR1F2 | |
| SCHEMBL6500127 | 0.86 | TRPM8 (0.58) | TRPM8CTRB1CTSBTACR1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037941-B2 | Alpha-and Beta-amino acid hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors | G. D. SEARLE & CO. (US) | 2006-05-02 | — | — | US | disclosed |
| US-6444678-B1 | α- and β-amino acid hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors | G. D. SEARLE & CO. | 2002-09-03 | — | — | US | disclosed |
| EP-0558603-B1 | RETROVIRAL PROTEASE INHIBITORS | MONSANTO CO (US) | 1998-08-26 | — | — | EP | disclosed |
| US-5708004-A | ENZYME INHIBITORS FOR TREATMENT OF AIDS | MONSANTO COMPANY (US) | 1998-01-13 | — | — | US | disclosed |
| EP-0554400-B1 | RETROVIRAL PROTEASE INHIBITORS | MONSANTO CO (US) | 1997-07-23 | — | — | EP | disclosed |
| US-5610190-A | Retroviral protease inhibitors | G. D. SEARLE & CO. (US) | 1997-03-11 | — | — | US | disclosed |
| EP-0735019-A2 | Retroviral protease inhibitors | MONSANTO COMPANY (US) | 1996-10-02 | — | — | EP | disclosed |
| EP-0731088-A2 | Retroviral protease inhibitors | MONSANTO COMPANY (US) | 1996-09-11 | — | — | EP | disclosed |
| US-5510378-A | Retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5475027-A | Retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 1995-12-12 | — | — | US | disclosed |
| EP-0554400-A1 | RETROVIRAL PROTEASE INHIBITORS. | MONSANTO CO (US) | 1993-08-11 | — | — | EP | disclosed |
| WO-1992008698-A1 | RETROVIRAL PROTEASE INHIBITORS | MONSANTO COMPANY (US) | 1992-05-29 | — | — | WO | disclosed |