Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 18/20 | 0.50 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5786088 | 0.90 | DPP4 (0.43) | CRHR1DPP4NPC1 | |
| SCHEMBL5785081 | 0.90 | DPP4 (0.43) | CRHR1DPP4NPC1 | |
| SCHEMBL5815735 | 0.88 | CRHR1 (0.49) | CRHR1DPP4NPC1 | |
| SCHEMBL5465128 | 0.87 | CRHR1 (0.52) | CRHR1 | |
| SCHEMBL5945279 | 0.79 | CRHR1 (0.52) | CRHR1 | |
| SCHEMBL5846977 | 0.79 | CRHR1 (0.53) | CRHR1 | |
| SCHEMBL5473168 | 0.78 | CRHR1 (0.45) | CRHR1 | |
| SCHEMBL2584391 | 0.78 | CRHR1 (0.42) | CRHR1 | |
| SCHEMBL6816578 | 0.77 | DPP4 (0.39) | CRHR1DPP4NPC1 | |
| SCHEMBL5804461 | 0.76 | NPC1 (0.50) | CRHR1DPP4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7074791-B2 | Pyrrolo[1,2-b]pyridazine compounds and their uses | PFIZER INC. (US) | 2006-07-11 | — | — | US | claimed |
| US-20040138221-A1 | Pyrrrolo[1,2-b]pyridazine compounds and their uses | PFIZER INC. | 2004-07-15 | — | — | US | claimed |
| WO-2004035586-A1 | PYRROLO[1,2-B]PYRIDAZINE COMPOUNDS AND THEIR USES | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-04-29 | — | — | WO | claimed |
| US-7074791-B2 | Pyrrolo[1,2-b]pyridazine compounds and their uses | PFIZER INC. (US) | 2006-07-11 | — | — | US | disclosed |
| US-20040138221-A1 | Pyrrrolo[1,2-b]pyridazine compounds and their uses | PFIZER INC. | 2004-07-15 | — | — | US | disclosed |
| WO-2004035586-A1 | PYRROLO[1,2-B]PYRIDAZINE COMPOUNDS AND THEIR USES | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-04-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138221-A1 | Pyrrrolo[1,2-b]pyridazine compounds and their uses | CRHR1, CRHR2, MC2R | CRHR1 1/4885DPP4 1497/4885NPC1 1920/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.