Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ACLY | P53396 | 3/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.33 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | PTPRS | Q13332 | 1/20 | 0.33 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5891856 | 0.93 | ACLY (0.36) | NR1H2NR1H3ALDH1A1ACLYPTPN1 | |
| SCHEMBL5891995 | 0.90 | NR1H2 (0.35) | NR1H2NR1H3TP53ALDH1A1KDM4E | |
| SCHEMBL5891989 | 0.85 | PTPN1 (0.37) | NR1H2NR1H3TP53ALDH1A1KDM4E | |
| SCHEMBL5167003 | 0.82 | PTPN5 (0.45) | NR1H2NR1H3ACLYPTPN1PTPN2 | |
| SCHEMBL5188719 | 0.80 | NR1H2 (0.33) | NR1H2NR1H3ACLYMCHR1HRH3 | |
| SCHEMBL5165795 | 0.80 | ACLY (0.33) | NR1H2NR1H3ACLYMCHR1PTPN1 | |
| SCHEMBL5891853 | 0.80 | PTPN1 (0.39) | NR1H2NR1H3ACLYPTPN1PTPN2 | |
| SCHEMBL5167825 | 0.78 | PTPN1 (0.38) | NR1H2NR1H3ACLYPTPN1PTPN2 | |
| SCHEMBL5188715 | 0.78 | PTPN1 (0.36) | NR1H2NR1H3ACLYMCHR1PTPN1 | |
| SCHEMBL5165791 | 0.78 | PTPN1 (0.36) | NR1H2NR1H3ACLYPTPN1PTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060135773-A1 | Trisubstituted nitrogen modulators of tyrosine phosphatases | METABASIS THERAPEUTICS, INC. | 2006-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135773-A1 | Trisubstituted nitrogen modulators of tyrosine phosphatases | PTPA, PTPN1, PTPRS | NR1H2 4860/4885NR1H3 4878/4885TP53 524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.