Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 9/20 | 0.55 |
| ▸ | PTPRA | P18433 | 1/20 | 0.51 |
| ▸ | AKT1 | P31749 | 1/20 | 0.50 |
| ▸ | CTSS | P25774 | 3/20 | 0.47 |
| ▸ | CTSK | P43235 | 2/20 | 0.47 |
| ▸ | CTSL | P07711 | 2/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.42 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5893307 | 0.98 | PTPN1 (0.53) | PTPN1PTPRAAKT1CTSSCTSK | |
| SCHEMBL6925818 | 0.91 | PTPN1 (0.47) | PTPN1PTPRAAKT1 | |
| SCHEMBL1731192 | 0.91 | PTPN1 (0.47) | PTPN1PTPRAAKT1 | |
| SCHEMBL1732762 | 0.87 | PTPN1 (0.54) | PTPN1PTPRA | |
| SCHEMBL1732761 | 0.87 | PTPN1 (0.54) | PTPN1PTPRA | |
| SCHEMBL1732320 | 0.86 | PTPN1 (0.47) | PTPN1PTPRAAKT1CTSSCTSK | |
| SCHEMBL6282167 | 0.85 | PTPN1 (0.62) | PTPN1CTSL | |
| SCHEMBL5893349 | 0.85 | PTPN1 (0.57) | PTPN1PTPRAAKT1CTSSCTSK | |
| SCHEMBL6141344 | 0.82 | PTPN1 (0.48) | PTPN1PTPRACTSSCTSL | |
| SCHEMBL1732436 | 0.81 | PTPN1 (0.53) | PTPN1PTPRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7141596-B2 | Inhibitors of proteins that bind phosphorylated molecules | INCYTE CORPORATION (US) | 2006-11-28 | — | — | US | disclosed |
| WO-2005035551-A2 | INHIBITORS OF PROTEINS THAT BIND PHOSPHORYLATED MOLECULES | INCYTE CORPORATION (US) | 2005-04-21 | — | — | WO | disclosed |