Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3676705 | 0.80 | MAPT (0.38) | MAPTGALR3KMT2AALDH1A1MEN1 | |
| SCHEMBL4299859 | 0.78 | MAPT (0.36) | MAPTGALR3KMT2A | |
| SCHEMBL13909523 | 0.78 | MAPT (0.36) | MAPTGALR3KMT2AALDH1A1MEN1 | |
| SCHEMBL5180050 | 0.70 | MAPT (0.35) | MAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL8434384 | 0.69 | KDM4E (0.40) | MAPTALDH1A1KDM4ECYP3A4MAPK1 | |
| SCHEMBL11860849 | 0.69 | ALDH1A1 (0.31) | MAPTALDH1A1 | |
| SCHEMBL3108876 | 0.68 | MAPT (0.31) | MAPTALDH1A1 | |
| SCHEMBL2929885 | 0.68 | MAPT (0.41) | MAPTGALR3KMT2AALDH1A1GLA | |
| SCHEMBL5179878 | 0.68 | MAPT (0.33) | MAPTKMT2AALDH1A1 | |
| SCHEMBL29105506 | 0.65 | MAPT (0.36) | MAPTALDH1A1CYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113717197-B | Preparation method and application of antituberculosis drug Pretomoid | 沈阳红旗制药有限公司 | 2023-09-12 | — | — | CN | claimed |
| CN-113717197-A | Preparation method and application of antituberculosis drug Pretomanid | 沈阳红旗制药有限公司 | 2021-11-30 | — | — | CN | claimed |
| WO-2024175804-A1 | NUCLEAR TRANSPORT MODULATORS | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2024-08-29 | — | — | WO | disclosed |
| CN-113717197-B | Preparation method and application of antituberculosis drug Pretomoid | 沈阳红旗制药有限公司 | 2023-09-12 | — | — | CN | disclosed |
| CN-113717197-B | Preparation method and application of antituberculosis drug Pretomoid | 沈阳红旗制药有限公司 | 2023-09-12 | — | — | CN | disclosed |
| CN-113717197-A | Preparation method and application of antituberculosis drug Pretomanid | 沈阳红旗制药有限公司 | 2021-11-30 | — | — | CN | disclosed |
| CN-113717197-A | Preparation method and application of antituberculosis drug Pretomanid | 沈阳红旗制药有限公司 | 2021-11-30 | — | — | CN | disclosed |
| CN-105439957-B | A kind of method of the bromo- 4- nitroimidazoles of synthesis 2- | 浙江省诸暨合力化学对外贸易有限公司 | 2018-05-08 | — | — | CN | disclosed |
| EP-2644599-B1 | Method for preparing a 2-halo-4-nitroimidazole compound | OTSUKA PHARMA CO LTD (JP) | 2014-12-10 | — | — | EP | disclosed |
| EP-2644599-A1 | Method for preparing 1-substituted-4-nitroimidazole compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-10-02 | — | — | EP | disclosed |
| US-20120130082-A1 | 1-Substituted-4-Nitroimidazole Compound and Method for Preparing the Same | OTSUKA PHARMACEUTICAL CO., LTD. | 2012-05-24 | — | — | US | disclosed |
| WO-2006035960-A2 | PROCESS FOR PRODUCTION OF 2-CHLORO-4-NITROIMIDAZOLE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-04-06 | — | — | WO | disclosed |
| WO-2005077913-A1 | METHOD FOR PRODUCING 4-NITROIMIDAZOLE COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-08-25 | — | — | WO | disclosed |
| EP-1553088-A1 | 1-SUBSTITUTED 4-NITROIMIDAZOLE COMPOUND AND PROCESS FOR PRODUCING THE SAME | Otsuka Pharmaceutical Company, Limited (JP) | 2005-07-13 | — | — | EP | disclosed |
| EP-0604409-B1 | OLIGONUCLEOTIDE ANALOGS FOR DETECTING AND MODULATING RNA ACTIVITY AND GENE EXPRESSION | ISIS PHARMACEUTICALS INC (US) | 2004-07-14 | — | — | EP | disclosed |
| EP-1418179-A2 | Compositions and methods for detecting and modulating rna activity and gene expression | ISIS PHARMACEUTICALS, INC. (US) | 2004-05-12 | — | — | EP | disclosed |
| US-6262241-B1 | ANTISENSE COMPOUNDS WHICH CLEAVE PHOSPHORODIESTER BONDS AND IMPROVE PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES OF OLIGONUCLEOTIDES, USEFUL IN DIAGNOSING DISEASES | ISIS PHARMACEUTICALS, INC. | 2001-07-17 | — | — | US | disclosed |
| EP-0604409-A4 | COMPOSITIONS AND METHODS FOR DETECTING AND MODULATING RNA ACTIVITY AND GENE EXPRESSION. | ISIS PHARMACEUTICALS INC (US) | 1996-06-12 | — | — | EP | disclosed |
| EP-0604409-A1 | COMPOSITIONS AND METHODS FOR DETECTING AND MODULATING RNA ACTIVITY AND GENE EXPRESSION | ISIS PHARMACEUTICALS, INC. (US) | 1994-07-06 | — | — | EP | disclosed |
| WO-1991010671-A1 | COMPOSITIONS AND METHODS FOR DETECTING AND MODULATING RNA ACTIVITY AND GENE EXPRESSION | ISIS PHARMACEUTICALS, INC. (US) | 1991-07-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120130082-A1 | 1-Substituted-4-Nitroimidazole Compound and Method for Preparing the Same | CBR1, CBR3, DCXR | MAPT 3906/4885GALR3 3023/4885MMP2 3936/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.