Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8436760 | 0.73 | ALDH1A1 (0.46) | ALDH1A1MAPK1PARP1PKMGPR84 | |
| SCHEMBL3676705 | 0.71 | MAPT (0.38) | ALDH1A1LMNAMAPT | |
| SCHEMBL9123535 | 0.70 | PARP1 (0.42) | ALDH1A1MAPK1PARP1GPR84GSK3B | |
| SCHEMBL18152663 | 0.69 | GAA (0.43) | KDM4EALDH1A1LMNAMAPTKCNJ1 | |
| SCHEMBL58940 | 0.69 | MAPT (0.38) | KDM4EALDH1A1MAPTMAPK1CYP3A4 | |
| SCHEMBL7608611 | 0.68 | KDM4E (0.85) | KDM4EALDH1A1LMNAMAPTKCNJ1 | |
| SCHEMBL7608604 | 0.68 | KDM4E (0.67) | KDM4EALDH1A1LMNAMAPTKCNJ1 | |
| SCHEMBL9122617 | 0.68 | ALDH1A1 (0.41) | ALDH1A1MAPK1PARP1PKMGPR84 | |
| SCHEMBL27431902 | 0.68 | ALDH1A1 (0.41) | ALDH1A1MAPK1PARP1PKMGPR84 | |
| SCHEMBL28455056 | 0.66 | ATM (0.49) | ALDH1A1MAPK1PKMGPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929249-A | ANGIOTENSIN II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-07-27 | — | — | US | disclosed |
| US-5728842-A | ANGIOTENSIN II RECEPTOR ANTAGONIST | SMITHKLINE BEECHAM CORPORATION (US) | 1998-03-17 | — | — | US | disclosed |
| EP-0653937-A4 | CHEMICAL COMPOUNDS. | SMITHKLINE BEECHAM CORP (US) | 1996-07-31 | — | — | EP | disclosed |
| EP-0653937-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-05-24 | — | — | EP | disclosed |
| WO-1994000120-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-01-06 | — | — | WO | disclosed |