Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 4/20 | 0.33 |
| ▸ | DRD4 | P21917 | 4/20 | 0.33 |
| ▸ | DRD3 | P35462 | 4/20 | 0.33 |
| ▸ | DRD1 | P21728 | 2/20 | 0.33 |
| ▸ | DRD5 | P21918 | 2/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.32 |
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | CDK9 | P50750 | 2/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.32 |
| ▸ | CCNT2 | O60583 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | AHR | P35869 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6998973 | 0.77 | ALDH1A1 (0.40) | MAOBDRD2DRD4DRD3AHR | |
| SCHEMBL5873762 | 0.72 | MAP3K11 (0.40) | ABL1DRD2DRD4DRD3DRD1 | |
| SCHEMBL18289479 | 0.70 | AHR (0.50) | DRD2DRD4DRD3DRD1DRD5 | |
| SCHEMBL28447107 | 0.66 | DRD2 (0.42) | MAOAMAOBDRD2DRD4DRD3 | |
| SCHEMBL5873807 | 0.65 | AHR (0.35) | DRD2DRD4DRD3DRD1DRD5 | |
| SCHEMBL18210028 | 0.64 | SRC (0.41) | DRD2DRD4DRD3DRD1DRD5 | |
| SCHEMBL2070779 | 0.64 | NEK2 (0.36) | DRD2DRD4DRD3SRCCDK5 | |
| SCHEMBL3340538 | 0.63 | AHR (0.48) | DRD2DRD4DRD3DRD1DRD5 | |
| SCHEMBL18289462 | 0.63 | AHR (0.52) | PDE3BPDE3AAHRCMA1PDK2 | |
| SCHEMBL30463280 | 0.63 | AHR (0.48) | DRD2DRD4DRD3DRD1DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7105529-B2 | Substituted oxindole derivatives as protein tyrosine and as protein serine/threonine kinase inhibitors and compositions and methods of treating chemotherapy and radiation therapy side effects | SMITHKLINE BEECHAM CORPORATION (US) | 2006-09-12 | — | — | US | disclosed |