Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 4/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.43 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5683634 | 0.82 | CHRM2 (0.51) | HRH1CHRM2CHRM1HTR2ACHRM5 | |
| SCHEMBL5894860 | 0.77 | KCNA5 (0.39) | LMNAHTTKMT2AKDM4EPOLB | |
| Diisopromine SCHEMBL25648 | 0.72 | HRH1 (0.63) | HRH1CHRM2CHRM1HTR2ACHRM5 | |
| SCHEMBL6757073 | 0.72 | CHRM3 (0.55) | HRH1CHRM2CHRM1HTR2ACHRM5 | |
| Diisopromine SCHEMBL11582569 | 0.71 | HRH1 (0.61) | HRH1CHRM2CHRM1HTR2ACHRM5 | |
| SCHEMBL724557 | 0.70 | CHRM3 (0.63) | HRH1CHRM2CHRM1HTR2ACHRM5 | |
| SCHEMBL724558 | 0.70 | CHRM3 (0.63) | HRH1CHRM2CHRM1HTR2ACHRM5 | |
| SCHEMBL8858816 | 0.70 | CHRM2 (0.55) | HRH1CHRM2CHRM1HTR2ACHRM5 | |
| SCHEMBL9225714 | 0.69 | CHRM2 (0.47) | HRH1CHRM2CHRM1HTR2ACHRM5 | |
| SCHEMBL3772844 | 0.68 | CHRM2 (0.44) | HRH1CHRM2CHRM1HTR2ACHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7119121-B2 | 3,3-diphenylpropylamines useful in therapy | PFIZER INC. (US) | 2006-10-10 | — | — | US | disclosed |
| US-20060004106-A1 | Novel 3,3-diphenylpropylamines useful in therapy | PFIZER INC | 2006-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004106-A1 | Novel 3,3-diphenylpropylamines useful in therapy | QDPR, HRH3, SLC7A1 | HRH1 86/4885CHRM2 115/4885CHRM1 181/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.