Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | DPEP1 | P16444 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5895867 | 1.00 | RAB9A (0.43) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL5895882 | 1.00 | RAB9A (0.43) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL5896607 | 0.91 | NPC1 (0.45) | RAB9ASMN1; SMN2NPC1ALDH1A1HPGD | |
| SCHEMBL5896552 | 0.91 | TDP1 (0.46) | RAB9ASMN1; SMN2NPC1ALDH1A1HPGD | |
| SCHEMBL5896535 | 0.91 | TDP1 (0.46) | RAB9ASMN1; SMN2NPC1ALDH1A1HPGD | |
| SCHEMBL5896356 | 0.91 | HPGD (0.39) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL5896546 | 0.91 | TDP1 (0.46) | RAB9ASMN1; SMN2NPC1ALDH1A1HPGD | |
| SCHEMBL5896363 | 0.91 | HPGD (0.39) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL5896595 | 0.91 | NPC1 (0.45) | RAB9ASMN1; SMN2NPC1ALDH1A1HPGD | |
| SCHEMBL5896603 | 0.91 | NPC1 (0.45) | RAB9ASMN1; SMN2NPC1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7041690-B2 | Inhibitors of HCV NS5B polymerase | PHARMACIA & UPJOHN COMPANY, LLC (US) | 2006-05-09 | — | — | US | disclosed |
| US-20060004063-A1 | Inhibitors of HCV NS5B polymerase | PHARMACIA & UPJOHN COMPANY, LLC | 2006-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004063-A1 | Inhibitors of HCV NS5B polymerase | POLRMT, EIF5B, POLI | RAB9A 1149/4885SMN1; SMN2 3496/4885NPC1 131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.