Sugi Predict

Sugi Predict / Compounds / SCHEMBL589651

SCHEMBL589651

SCHEMBL589651

NS(=O)(=O)c1cc(C(=O)O)c(O)c2ccccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ MCL1 Q07820 15/20 1.00
▸ HSD17B10 Q99714 3/20 1.00
▸ CYP2C9 P11712 2/20 1.00
▸ THRB P10828 1/20 0.69
▸ HPGD P15428 2/20 0.59
▸ TSHR P16473 1/20 0.59
▸ ALOX12 P18054 1/20 0.59
▸ ATIC P31939 1/20 0.59
▸ GLO1 Q04760 1/20 0.57
▸ BCL2L1 Q07817 3/20 0.57
▸ KDM4E B2RXH2 1/20 0.56
▸ MEN1 O00255 1/20 0.56
▸ ALDH1A1 P00352 1/20 0.56
▸ MAPT P10636 1/20 0.56
▸ PKM P14618 1/20 0.56
▸ HTT P42858 1/20 0.56
▸ KMT2A Q03164 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1806130 0.88 MCL1 (0.79) MCL1HSD17B10CYP2C9THRBHPGD
SCHEMBL1808593 0.85 MCL1 (0.73) MCL1HSD17B10CYP2C9THRBHPGD
SCHEMBL590115 0.83 MCL1 (0.71) MCL1HSD17B10CYP2C9THRBHPGD
SCHEMBL7234615 0.83 MCL1 (0.71) MCL1HSD17B10CYP2C9THRBHPGD
SCHEMBL1805256 0.83 MCL1 (0.71) MCL1HSD17B10CYP2C9THRBGLO1
SCHEMBL29539793 0.83 MCL1 (0.71) MCL1HSD17B10CYP2C9THRBHPGD
SCHEMBL13543238 0.83 MCL1 (0.70) MCL1HSD17B10CYP2C9THRBGLO1
SCHEMBL317180 0.82 THRB (1.00) MCL1HSD17B10CYP2C9THRBHPGD
SCHEMBL2789013 0.82 MCL1 (0.69) MCL1HSD17B10CYP2C9THRBHPGD
SCHEMBL1808814 0.82 MCL1 (0.69) MCL1HSD17B10CYP2C9THRBHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12163968-B2 Preparation of nucleated RBC (NRBC) analogs for use as reference hematology controls in automated hematology analyzers BIO-RAD LABORATORIES, INC. (US) 2024-12-10 — — US claimed
EP-3319938-B1 SMALL MOLECULE INHIBITORS OF THE MCL-1 ONCOPROTEIN AND USES THEREOF UNIV MARYLAND (US) 2022-04-06 — — EP claimed
US-20180208554-A1 Small Molecule Inhibitors of the MCL-1 Oncoprotein and Uses Thereof UNIVERSITY OF MARYLAND, BALTIMORE 2018-07-26 — — US claimed
EP-3319938-A1 SMALL MOLECULE INHIBITORS OF THE MCL-1 ONCOPROTEIN AND USES THEREOF University of Maryland, Baltimore (US) 2018-05-16 — — EP claimed
WO-2017011323-A1 SMALL MOLECULE INHIBITORS OF THE MCL-1 ONCOPROTEIN AND USES THEREOF UNIVERSITY OF MARYLAND, BALTIMORE (US) 2017-01-19 — — WO claimed
US-5403750-A Polyetherurethanes modified with amine, mercpto or hydroxyl functional groups W. R. GRACE & CO.-CONN. (US) 1995-04-04 — — US claimed
US-12163968-B2 Preparation of nucleated RBC (NRBC) analogs for use as reference hematology controls in automated hematology analyzers BIO-RAD LABORATORIES, INC. (US) 2024-12-10 — — US disclosed
EP-4208021-A1 PREPARATION OF NUCLEATED RBC (NRBC) ANALOGS FOR USE AS REFERENCE HEMATOLOGY CONTROLS IN AUTOMATED HEMATOLOGY ANALYZERS Bio-Rad Laboratories, Inc. (US) 2023-07-12 — — EP disclosed
US-20220396549-A1 SMALL MOLECULE INHIBITORS OF THE MCL-1 ONCOPROTEIN AND USES THEROF UNIV MARYLAND (US) 2022-12-15 — — US disclosed
US-20220396549-A1 SMALL MOLECULE INHIBITORS OF THE MCL-1 ONCOPROTEIN AND USES THEROF UNIV MARYLAND (US) 2022-12-15 — — US disclosed
EP-3319938-B1 SMALL MOLECULE INHIBITORS OF THE MCL-1 ONCOPROTEIN AND USES THEREOF UNIV MARYLAND (US) 2022-04-06 — — EP disclosed
WO-2022051443-A1 PREPARATION OF NUCLEATED RBC (NRBC) ANALOGS FOR USE AS REFERENCE HEMATOLOGY CONTROLS IN AUTOMATED HEMATOLOGY ANALYZERS BIO-RAD LABORATORIES, INC. (US) 2022-03-10 — — WO disclosed
US-20220065878-A1 PREPARATION OF NUCLEATED RBC (NRBC) ANALOGS FOR USE AS REFERENCE HEMATOLOGY CONTROLS IN AUTOMATED HEMATOLOGY ANALYZERS BIO-RAD LABORATORIES, INC. 2022-03-03 — — US disclosed
CN-1199399-A Naphthamide derivs, of 3-beta-amino azabicyclo octane or nonane as neuroleptic agents PF MEDICAMENT (FR) 1998-11-18 — — CN disclosed
US-5403750-A Polyetherurethanes modified with amine, mercpto or hydroxyl functional groups W. R. GRACE & CO.-CONN. (US) 1995-04-04 — — US disclosed
EP-0367362-B1 Chemically modified hydrophilic prepolymers and polymers GRACE W R & CO (US) 1994-06-15 — — EP disclosed
US-4940737-A Biocompatible polyurethane three-dimensional hydrogels or foams W. R. GRACE & CO.-CONN (US) 1990-07-10 — — US disclosed
EP-0367362-A2 Chemically modified hydrophilic prepolymers and polymers W.R. Grace & Co.-Conn. (US) 1990-05-09 — — EP disclosed
US-4533625-A COLOR COUPLER COMPRISING HYDROXYNAPHTHYL-SULFONYL OR -SULFINYL COMPOUND FUJI PHOTO FILM CO., LTD. (JP) 1985-08-06 — — US disclosed
US-4247597-A Electroscopic carrier particles having a carboxylic acid surface treatment PITNEY BOWES, INC. (US) 1981-01-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220396549-A1 SMALL MOLECULE INHIBITORS OF THE MCL-1 ONCOPROTEIN AND USES THEROF MCL1, TP53, MYC MCL1 1/4885HSD17B10 4280/4885CYP2C9 4854/4885
US-20180208554-A1 Small Molecule Inhibitors of the MCL-1 Oncoprotein and Uses Thereof MCL1, BCL3, BCL9 MCL1 1/4885HSD17B10 3795/4885CYP2C9 4851/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.