Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 17/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.71 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.59 |
| ▸ | ATIC | P31939 | 1/20 | 0.59 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29539793 | 1.00 | MCL1 (0.71) | MCL1HSD17B10CYP2C9HPGDKDM4E | |
| SCHEMBL1808593 | 0.85 | MCL1 (0.73) | MCL1HSD17B10CYP2C9HPGDKDM4E | |
| SCHEMBL590115 | 0.83 | MCL1 (0.71) | MCL1HSD17B10CYP2C9HPGDKDM4E | |
| SCHEMBL589651 | 0.83 | MCL1 (1.00) | MCL1HSD17B10CYP2C9HPGDKDM4E | |
| SCHEMBL2789013 | 0.82 | MCL1 (0.69) | MCL1HSD17B10CYP2C9HPGDKDM4E | |
| SCHEMBL181076 | 0.80 | MPL (0.45) | MCL1HSD17B10CYP2C9HPGDKDM4E | |
| SCHEMBL18392411 | 0.80 | MCL1 (1.00) | MCL1HSD17B10CYP2C9HPGDTHRB | |
| SCHEMBL30076571 | 0.80 | MCL1 (1.00) | MCL1HSD17B10CYP2C9HPGDTHRB | |
| SCHEMBL30076624 | 0.78 | MCL1 (0.85) | MCL1BCL2L1 | |
| SCHEMBL9110910 | 0.78 | MCL1 (0.54) | MCL1HSD17B10CYP2C9HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220396549-A1 | SMALL MOLECULE INHIBITORS OF THE MCL-1 ONCOPROTEIN AND USES THEROF | UNIV MARYLAND (US) | 2022-12-15 | — | — | US | disclosed |
| EP-3319938-B1 | SMALL MOLECULE INHIBITORS OF THE MCL-1 ONCOPROTEIN AND USES THEREOF | UNIV MARYLAND (US) | 2022-04-06 | — | — | EP | disclosed |
| US-10858316-B2 | Small molecule inhibitors of the MCL-1 oncoprotein and uses thereof | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2020-12-08 | — | — | US | disclosed |
| US-10858316-B2 | Small molecule inhibitors of the MCL-1 oncoprotein and uses thereof | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2020-12-08 | — | — | US | disclosed |
| US-20180208554-A1 | Small Molecule Inhibitors of the MCL-1 Oncoprotein and Uses Thereof | UNIVERSITY OF MARYLAND, BALTIMORE | 2018-07-26 | — | — | US | disclosed |
| US-20180208554-A1 | Small Molecule Inhibitors of the MCL-1 Oncoprotein and Uses Thereof | UNIVERSITY OF MARYLAND, BALTIMORE | 2018-07-26 | — | — | US | disclosed |
| WO-2017011323-A1 | SMALL MOLECULE INHIBITORS OF THE MCL-1 ONCOPROTEIN AND USES THEREOF | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2017-01-19 | — | — | WO | disclosed |
| US-6541491-B1 | Treating ras mediated diseases, especially cancer. | ZENECA LIMITED (GB) | 2003-04-01 | — | — | US | disclosed |
| CN-1101380-C | 4-mercaptopyrrolidine derivatives as farnesyl transferase inhibitors | ZENECA LTD (GB) | 2003-02-12 | — | — | CN | disclosed |
| CN-1377647-A | 4-mercaptopyrrolidinyl derivative as fernesyl transferase inhibitor | ZENECA LTD (GB) | 2002-11-06 | — | — | CN | disclosed |
| US-6232338-B1 | 4-Mercaptopyrrolidine derivatives as farnesyl transferase inhibitors | ZENECA LIMITED (GB) | 2001-05-15 | — | — | US | disclosed |
| CN-1197453-A | 4-mercaptopyrrolidine derivatives as farnesyl transferase inhibitors | ZENECA LTD (GB) | 1998-10-28 | — | — | CN | disclosed |
| EP-0842151-A1 | 4-MERCAPTOPYRROLIDINE DERIVATIVES AS FARNESYL TRANSFERASE INHIBITORS | ZENECA LIMITED (GB) | 1998-05-20 | — | — | EP | disclosed |
| WO-1997006138-A1 | 4-MERCAPTOPYRROLIDINE DERIVATIVES AS FARNESYL TRANSFERASE INHIBITORS | ZENECA LIMITED (GB) | 1997-02-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220396549-A1 | SMALL MOLECULE INHIBITORS OF THE MCL-1 ONCOPROTEIN AND USES THEROF | MCL1, TP53, MYC | MCL1 1/4885HSD17B10 4280/4885CYP2C9 4854/4885 |
| US-10858316-B2 | Small molecule inhibitors of the MCL-1 oncoprotein and uses thereof | MCL1, BCL3, BCL9 | MCL1 1/4885HSD17B10 3795/4885CYP2C9 4851/4885 |
| US-20180208554-A1 | Small Molecule Inhibitors of the MCL-1 Oncoprotein and Uses Thereof | MCL1, BCL3, BCL9 | MCL1 1/4885HSD17B10 3795/4885CYP2C9 4851/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.