Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.33 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.33 |
| ▸ | TERT | O14746 | 3/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | UNG | P13051 | 2/20 | 0.35 |
| ▸ | TOP1 | P11387 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | MLNR | O43193 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2199193 | 0.91 | TERT (0.44) | TERTENPP2ABCG2TOP1CYP2D6 | |
| Hydrochloric Acid SCHEMBL588418 | 0.91 | TERT (0.44) | TERTENPP2ABCG2TOP1CYP2D6 | |
| SCHEMBL12057454 | 0.90 | TERT (0.43) | TERTENPP2ABCG2TOP1CYP2D6 | |
| SCHEMBL12057455 | 0.90 | TERT (0.43) | TERTENPP2ABCG2TOP1CYP2D6 | |
| Hydrochloric Acid SCHEMBL585205 | 0.89 | TERT (0.44) | TERTENPP2ABCG2TOP1CYP2D6 | |
| Hydrochloric Acid SCHEMBL585082 | 0.89 | TERT (0.44) | TERTENPP2ABCG2TOP1CYP2D6 | |
| Hydrochloric Acid SCHEMBL2202699 | 0.89 | TERT (0.44) | TERTENPP2ABCG2TOP1CYP2D6 | |
| Hydrochloric Acid SCHEMBL585437 | 0.89 | TERT (0.44) | TERTENPP2ABCG2TOP1CYP2D6 | |
| Hydrochloric Acid SCHEMBL585452 | 0.89 | TERT (0.44) | TERTENPP2ABCG2TOP1CYP2D6 | |
| Hydrochloric Acid SCHEMBL2197145 | 0.89 | TERT (0.44) | TERTENPP2ABCG2TOP1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1768666-B1 | NOVEL USES OF PORPHYRIN COMPOUNDS | DESTINY PHARMA LTD (GB) | 2012-02-15 | — | — | EP | disclosed |