Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CHKA | P35790 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.37 |
| ▸ | HTR3B | O95264 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5897129 | 0.94 | HRH4 (0.55) | HRH4NPSR1KMT2AKDM4ECRHBP | |
| SCHEMBL5896965 | 0.77 | HRH3 (0.43) | HRH4NPSR1KMT2AKDM4EHSD17B10 | |
| SCHEMBL4781313 | 0.76 | KMT2A (0.51) | HRH4NPSR1KMT2AKDM4EHSD17B10 | |
| SCHEMBL20907277 | 0.75 | CHKA (0.62) | ROCK2ROCK1NCF1KMT2AKDM4E | |
| SCHEMBL13929505 | 0.74 | HRH4 (0.68) | HRH4NPSR1KMT2AKDM4ECRHBP | |
| SCHEMBL3634900 | 0.73 | HRH4 (0.61) | HRH4NPSR1KMT2ACRHBPCRHR2 | |
| SCHEMBL7676555 | 0.72 | CYP1A2 (0.50) | KMT2ACRHBPCRHR2 | |
| SCHEMBL2166591 | 0.70 | HRH4 (0.73) | HRH4NPSR1CRHBPCRHR2 | |
| SCHEMBL1774531 | 0.69 | CYP2C19 (0.61) | HRH4NPSR1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL2321570 | 0.69 | ROCK2 (0.63) | HRH4NPSR1ROCK2ROCK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060700-B2 | Amide derivatives useful as inhibitors of the production of cytokines | ASTRAZENECA AB (SE) | 2006-06-13 | — | — | US | disclosed |