Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.69 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | TSHR | P16473 | 2/20 | 0.69 |
| ▸ | GLA | P06280 | 1/20 | 0.69 |
| ▸ | EIF4E | P06730 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | TOP1 | P11387 | 1/20 | 0.69 |
| ▸ | THPO | P40225 | 1/20 | 0.69 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.69 |
| ▸ | PNP | P00491 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6913779 | 0.89 | LMNA (0.54) | LMNASMN1; SMN2ADORA1ALDH1A1TSHR | |
| SCHEMBL6918155 | 0.87 | LMNA (0.52) | LMNASMN1; SMN2ADORA1ALDH1A1TSHR | |
| SCHEMBL6908769 | 0.86 | LMNA (0.51) | LMNASMN1; SMN2ADORA1ALDH1A1TSHR | |
| SCHEMBL6916796 | 0.86 | LMNA (0.51) | LMNASMN1; SMN2ADORA1ALDH1A1TSHR | |
| Ribavirin SCHEMBL18486574 | 0.86 | LMNA (0.82) | LMNASMN1; SMN2ADORA1ALDH1A1TSHR | |
| SCHEMBL15031296 | 0.85 | LMNA (0.74) | LMNASMN1; SMN2ADORA1ALDH1A1TSHR | |
| Ribavirin SCHEMBL1200226 | 0.85 | LMNA (0.90) | LMNASMN1; SMN2ADORA1ALDH1A1TSHR | |
| Ribavirin SCHEMBL572829 | 0.85 | LMNA (0.90) | LMNASMN1; SMN2ADORA1ALDH1A1TSHR | |
| Ribavirin SCHEMBL5473652 | 0.84 | LMNA (0.88) | LMNASMN1; SMN2ADORA1ALDH1A1TSHR | |
| SCHEMBL12879138 | 0.84 | LMNA (0.68) | LMNASMN1; SMN2ADORA1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7083961-B1 | Crystal structures of T. foetus inosine monophosphate dehydrogenase in complex with substrate, cofactor and analogs and uses thereof | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-08-01 | — | — | US | claimed |