Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 5/20 | 0.80 |
| ▸ | MMP9 | P14780 | 2/20 | 0.76 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.75 |
| ▸ | MMP12 | P39900 | 2/20 | 0.69 |
| ▸ | MMP3 | P08254 | 1/20 | 0.69 |
| ▸ | MMP7 | P09237 | 1/20 | 0.69 |
| ▸ | MMP10 | P09238 | 1/20 | 0.69 |
| ▸ | MMP8 | P22894 | 1/20 | 0.69 |
| ▸ | MMP13 | P45452 | 1/20 | 0.69 |
| ▸ | MMP14 | P50281 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5898406 | 1.00 | MMP2 (0.80) | MMP2MMP9ADAM17MMP12MMP3 | |
| Trifluoroacetic Acid SCHEMBL5898269 | 1.00 | MMP2 (0.80) | MMP2MMP9ADAM17MMP12MMP3 | |
| Trifluoroacetic Acid SCHEMBL5898402 | 1.00 | MMP2 (0.80) | MMP2MMP9ADAM17MMP12MMP3 | |
| SCHEMBL5898083 | 0.96 | MMP2 (0.85) | MMP2MMP9ADAM17MMP12MMP3 | |
| SCHEMBL5898081 | 0.96 | MMP2 (0.85) | MMP2MMP9ADAM17MMP12MMP3 | |
| SCHEMBL5898077 | 0.96 | MMP2 (0.85) | MMP2MMP9ADAM17MMP12MMP3 | |
| SCHEMBL5898075 | 0.96 | MMP2 (0.85) | MMP2MMP9ADAM17MMP12MMP3 | |
| SCHEMBL5898090 | 0.96 | MMP2 (0.85) | MMP2MMP9ADAM17MMP12MMP3 | |
| Trifluoroacetic Acid SCHEMBL5897873 | 0.94 | ADAM17 (0.73) | MMP2MMP9ADAM17 | |
| Trifluoroacetic Acid SCHEMBL5898382 | 0.94 | ADAM17 (0.73) | MMP2MMP9ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6984648-B2 | Cyclic β-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-α | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2006-01-10 | — | — | US | disclosed |
| US-20040162426-A1 | Cyclic beta-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-alpha | LU ZHONGHUI (US) | 2004-08-19 | — | — | US | disclosed |
| US-6743807-B2 | TREATMENT OF RHEUMATOID AND OSTEOARTHRITIS, CORNEAL, EPIDERMAL OR GASTRIC ULCERATION, TUMOR METASTASIS OR INVASION, PERIODONTAL DISEASE AND BONE DISEASE | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-06-01 | — | — | US | disclosed |
| US-20020016336-A1 | Cyclic beta-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-alpha | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020016336-A1 | Cyclic beta-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-alpha | RNPEP, TNF, ANPEP | MMP2 8/4885MMP9 4/4885ADAM17 18/4885 |
| US-20040162426-A1 | Cyclic beta-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-alpha | RNPEP, TNF, ANPEP | MMP2 8/4885MMP9 4/4885ADAM17 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.