Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5899161 | 1.00 | OPRM1 (0.52) | OPRM1OPRD1OPRK1 | |
| SCHEMBL5899136 | 0.90 | OPRM1 (0.51) | OPRM1OPRD1OPRK1 | |
| SCHEMBL5899134 | 0.90 | OPRM1 (0.51) | OPRM1OPRD1OPRK1 | |
| SCHEMBL5899180 | 0.85 | OPRM1 (0.52) | OPRM1OPRD1OPRK1 | |
| SCHEMBL5899181 | 0.85 | OPRM1 (0.52) | OPRM1OPRD1OPRK1 | |
| SCHEMBL5899195 | 0.83 | OPRM1 (0.53) | OPRM1OPRD1 | |
| SCHEMBL5899196 | 0.83 | OPRM1 (0.53) | OPRM1OPRD1 | |
| SCHEMBL5899192 | 0.83 | OPRM1 (0.52) | OPRM1OPRD1OPRK1 | |
| SCHEMBL5899138 | 0.83 | OPRM1 (0.51) | OPRM1OPRD1OPRK1 | |
| SCHEMBL5899191 | 0.83 | OPRM1 (0.52) | OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7012083-B2 | Compounds useful in therapy | PFIZER INC. (US) | 2006-03-14 | — | — | US | disclosed |
| US-20020099214-A1 | Compounds useful in therapy | PFIZER INC. (US) | 2002-07-25 | — | — | US | disclosed |
| EP-1072594-A2 | 4-arylpiperidine derivatives for the treatment of pruritus | PFIZER INC. (US) | 2001-01-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020099214-A1 | Compounds useful in therapy | HRH2, ITCH, HRH4 | OPRM1 72/4885OPRD1 41/4885OPRK1 57/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.