Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.36 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.36 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5899733 | 0.92 | EPHX2 (0.41) | ALDH1A1SMN1; SMN2HTTTSHREPHX2 | |
| SCHEMBL5899565 | 0.86 | TSHR (0.40) | ALDH1A1SMN1; SMN2TSHRSLC1A1SLC1A3 | |
| SCHEMBL20295088 | 0.73 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2HTTTSHREPHX2 | |
| SCHEMBL25237906 | 0.71 | TSHR (0.47) | ALDH1A1TSHREPHX2KDM4EPOLB | |
| SCHEMBL4161505 | 0.71 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2HTTTSHREPHX2 | |
| SCHEMBL6651296 | 0.71 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2HTTTSHREPHX2 | |
| SCHEMBL3369328 | 0.71 | MAOA (0.52) | ALDH1A1TSHRKDM4EPOLB | |
| SCHEMBL20703744 | 0.70 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2HTTTSHREPHX2 | |
| SCHEMBL16761714 | 0.70 | EPHX2 (0.45) | ALDH1A1SMN1; SMN2HTTTSHREPHX2 | |
| SCHEMBL5899630 | 0.69 | EPHX2 (0.42) | SMN1; SMN2HTTTSHREPHX2TEAD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7030267-B2 | Cycloproply β-amino acid derivatives | WARNER-LAMBERT COMPANY, LLC (US) | 2006-04-18 | — | — | US | disclosed |
| US-20040147608-A1 | Cyclopropyl beta-amino acid derivatives | SCHWARZ JACOB BRADLEY (US) | 2004-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147608-A1 | Cyclopropyl beta-amino acid derivatives | CACNA1S, CACNA1D, CACNA1B | ALDH1A1 1295/4885SMN1; SMN2 627/4885HTT 2294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.