Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.79 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.49 |
| ▸ | HPGD | P15428 | 9/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | AGER | Q15109 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5273533 | 0.88 | CYP2C9 (1.00) | CYP2C9MEN1POLBKMT2AALDH1A1 | |
| SCHEMBL14384569 | 0.81 | CYP2C9 (0.70) | CYP2C9MEN1POLBKMT2AALDH1A1 | |
| SCHEMBL5272845 | 0.80 | CYP2C9 (0.76) | CYP2C9POLBKMT2AALDH1A1KDM4E | |
| SCHEMBL5284518 | 0.75 | KDM4E (0.60) | CYP2C9ALDH1A1KDM4EHPGDGAA | |
| SCHEMBL4579574 | 0.74 | CYP2C9 (0.61) | CYP2C9POLBALDH1A1KDM4EHPGD | |
| SCHEMBL10681805 | 0.70 | KDM4E (0.64) | CYP2C9MEN1POLBKMT2AALDH1A1 | |
| SCHEMBL26743702 | 0.70 | HPGD (0.78) | CYP2C9ALDH1A1KDM4EHPGDGAA | |
| SCHEMBL238765 | 0.70 | AGER (0.70) | AGERAR | |
| SCHEMBL4606977 | 0.70 | CYP2C9 (0.56) | CYP2C9MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL7141330 | 0.70 | CYP2C9 (0.64) | CYP2C9POLBALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060183182-A1 | Enzyme substrate | SMITHKLINE BEECHAM P.L.C. | 2006-08-17 | — | — | US | disclosed |
| EP-1307586-B1 | ENZYME SUBSTRATE | SMITHKLINE BEECHAM PLC (GB) | 2004-07-07 | — | — | EP | disclosed |
| EP-1307586-A2 | ENZYME SUBSTRATE | SMITHKLINE BEECHAM PLC (GB) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002012542-A2 | ENZYME SUBSTRATE | SMITHKLINE BEECHAM PLC (GB) | 2002-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060183182-A1 | Enzyme substrate | CYP3A43, CYP2E1, CYP3A4 | CYP2C9 10/4885MEN1 4502/4885POLB 2661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.