Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sumanirole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 6/20 | 0.97 |
| ▸ | HTR1A | P08908 | 18/20 | 0.97 |
| ▸ | DRD3 | P35462 | 6/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sumanirole SCHEMBL6269816 | 0.99 | HTR1A (1.00) | HTR1ADRD2DRD3 | |
| Sumanirole SCHEMBL29518262 | 0.99 | HTR1A (1.00) | HTR1ADRD2DRD3 | |
| Sumanirole SCHEMBL30503038 | 0.99 | HTR1A (1.00) | HTR1ADRD2DRD3 | |
| Sumanirole SCHEMBL154412 | 0.99 | HTR1A (1.00) | HTR1ADRD2DRD3 | |
| Sumanirole SCHEMBL1229224 | 0.89 | HTR1A (0.82) | HTR1ADRD2DRD3 | |
| Sumanirole SCHEMBL7046470 | 0.89 | HTR1A (0.82) | HTR1ADRD2DRD3 | |
| SCHEMBL1752535 | 0.82 | HTR1A (0.71) | HTR1ADRD2DRD3 | |
| SCHEMBL5141708 | 0.82 | HTR1A (0.71) | HTR1ADRD2DRD3 | |
| SCHEMBL30730650 | 0.82 | HTR1A (1.00) | HTR1ADRD2DRD3 | |
| SCHEMBL6507236 | 0.82 | HTR1A (1.00) | HTR1ADRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060040929-A1 | (5R)-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline-2(1H)-thione and method of preparation thereof | MCCALL ROBERT B | 2006-02-23 | — | — | US | disclosed |
| WO-2001083483-A1 | (5R)-(METHYLAMINO)-5,6-DIHYDRO-4H-IMIDAZO[4,5,1-ij]QUINOLINE-2(1H)-THIONE | PHARMACIA & UPJOHN COMPANY (US) | 2001-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060040929-A1 | (5R)-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline-2(1H)-thione and method of preparation thereof | CYP3A5, UGT1A1, SULT1A1 | DRD2 446/4885HTR1A 81/4885DRD3 822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.