Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 3/20 | 0.49 |
| ▸ | NPR3 | P17342 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.36 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5906799 | 1.00 | PDK1 (0.49) | PDK1NPR3CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL5906901 | 0.82 | ADORA2A (0.42) | PDK1NPR3CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL5906905 | 0.82 | ADORA2A (0.42) | PDK1NPR3CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL5906688 | 0.78 | MME (0.50) | NPR3GPR142PPARGPPARAACE | |
| SCHEMBL5906686 | 0.78 | MME (0.50) | NPR3GPR142PPARGPPARAACE | |
| SCHEMBL5906830 | 0.76 | NPR3 (0.52) | NPR3CYP3A4CYP2C8CYP2C9CYP2C19 | |
| SCHEMBL5906828 | 0.76 | PPARG (0.54) | PPARGPPARAACEITGA4 | |
| SCHEMBL5906832 | 0.76 | PPARG (0.54) | PPARGPPARAACEITGA4 | |
| SCHEMBL5906834 | 0.76 | ADORA2A (0.41) | PDK1NPR3CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL5906838 | 0.76 | ADORA2A (0.41) | PDK1NPR3CYP3A4CYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060089371-A1 | Phenyl or heteroaryl amino alkane derivatives as ip receptor antagonist | BAYER HEALTHCARE AG (DE) | 2006-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060089371-A1 | Phenyl or heteroaryl amino alkane derivatives as ip receptor antagonist | BPHL, HRH4, HRH2 | PDK1 1202/4885NPR3 444/4885CYP3A4 453/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.