Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 1/20 | 0.58 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 6/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 6/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SCD | O00767 | 2/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5909096 | 0.86 | RBP4 (0.57) | RBP4NAMPTTP53MDM2PSEN1 | |
| SCHEMBL5909108 | 0.85 | RBP4 (0.61) | RBP4NAMPTTP53MDM2PSEN1 | |
| SCHEMBL7095639 | 0.84 | RBP4 (0.65) | RBP4NAMPTTP53MDM2PSEN1 | |
| SCHEMBL29944078 | 0.82 | RBP4 (0.64) | RBP4NAMPTTP53MDM2PSEN1 | |
| SCHEMBL2818661 | 0.82 | RBP4 (0.58) | RBP4NAMPTTP53MDM2PSEN1 | |
| Hydrochloric Acid SCHEMBL2819736 | 0.81 | RBP4 (0.57) | RBP4NAMPTTP53MDM2PSEN1 | |
| SCHEMBL2818657 | 0.81 | RBP4 (0.59) | RBP4NAMPTTP53MDM2PSEN1 | |
| SCHEMBL14595381 | 0.80 | KDM4E (0.44) | MDM2POLB | |
| SCHEMBL14595382 | 0.80 | HSD11B1 (0.43) | NPC1POLB | |
| SCHEMBL5909231 | 0.79 | RBP4 (0.63) | RBP4TP53MDM2SCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060030557-A1 | Substituted pyridines having antiangiogenic activity | HAVIV FORTUNA | 2006-02-09 | — | — | US | disclosed |
| US-20040014744-A1 | Substituted pyridines having antiangiogenic activity | ABBOTT LABORATORIES | 2004-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014744-A1 | Substituted pyridines having antiangiogenic activity | FLT1, FLT4, KDR | RBP4 1405/4885NAMPT 226/4885TP53 593/4885 |
| US-20060030557-A1 | Substituted pyridines having antiangiogenic activity | FLT4, KDR, FLT1 | RBP4 1151/4885NAMPT 140/4885TP53 485/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.