Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | F7 | P08709 | 1/20 | 0.41 |
| ▸ | F3 | P13726 | 1/20 | 0.41 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.41 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.41 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL592670 | 0.84 | MEN1 (0.43) | ALDH1A1KDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL10544590 | 0.84 | AKR1C3 (0.46) | ALDH1A1GAAMAPTMEN1KMT2A | |
| SCHEMBL4872400 | 0.79 | RAB9A (0.46) | ALDH1A1MAPTHDAC6MEN1KMT2A | |
| SCHEMBL592680 | 0.78 | LIG1 (0.47) | ALDH1A1GAAHPGDPOLBHSD17B10 | |
| SCHEMBL28310989 | 0.77 | AKR1C3 (0.47) | ALDH1A1GAAHPGDPOLBMAPT | |
| SCHEMBL6707631 | 0.77 | LTA4H (0.40) | ALDH1A1GAAHPGDMAPTKDM4E | |
| SCHEMBL593214 | 0.77 | GAA (0.37) | GAAHPGDMAPTHTT | |
| SCHEMBL29378767 | 0.77 | AKR1C3 (0.47) | ALDH1A1GAAHPGDPOLBMAPT | |
| SCHEMBL29967571 | 0.75 | HPGD (0.41) | ALDH1A1STAT3HPGDPOLBHSD17B10 | |
| SCHEMBL3243204 | 0.74 | LIG1 (0.42) | ALDH1A1HPGDHSD17B10GFERKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8114882-B2 | Antitumor agents; kinase inhibitors; angiogenesis inhibitors; arteriosclerosis ; antiinflammatory agents | MERCK PATENT GMBH (DE) | 2012-02-14 | — | — | US | disclosed |
| EP-1874760-B1 | (LH-IND0L-7-YL)-( (PYRIMIDIN-2 -YL-AMINO) METHANONE DERIVATIVES AND RELATED COMPOUNDS AS IGF-RL INHIBITORS FOR TREATING CANCER | MERCK PATENT GMBH (DE) | 2010-10-06 | — | — | EP | disclosed |