Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 3/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5914170 | 0.92 | ALDH1A1 (0.38) | CYP1A2CYP3A4SMN1; SMN2ALDH1A1CYP2D6 | |
| SCHEMBL5914274 | 0.90 | MAPK14 (0.37) | CYP1A2CYP3A4SMN1; SMN2ALDH1A1CYP2D6 | |
| SCHEMBL5914397 | 0.88 | ALDH1A1 (0.34) | CYP1A2CYP3A4SMN1; SMN2ALDH1A1CYP2D6 | |
| SCHEMBL5914396 | 0.87 | KDM4E (0.42) | CYP1A2CYP3A4SMN1; SMN2ALDH1A1CYP2D6 | |
| SCHEMBL5913976 | 0.87 | MAPK14 (0.36) | CYP1A2CYP3A4SMN1; SMN2ALDH1A1CYP2D6 | |
| SCHEMBL5914336 | 0.84 | CYP1A2 (0.38) | CYP1A2CYP3A4SMN1; SMN2ALDH1A1CYP2D6 | |
| SCHEMBL5914230 | 0.84 | CYP1A2 (0.33) | CYP1A2CYP3A4SMN1; SMN2ALDH1A1CYP2D6 | |
| SCHEMBL5914432 | 0.84 | MMP2 (0.42) | CYP1A2CYP3A4ALDH1A1CYP2D6MAPK14 | |
| SCHEMBL5914435 | 0.84 | MMP2 (0.42) | CYP1A2CYP3A4ALDH1A1CYP2D6MAPK14 | |
| SCHEMBL5914034 | 0.82 | ALDH1A1 (0.42) | CYP1A2CYP3A4ALDH1A1CYP2D6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060069110-A1 | Substituted heterocyclic compounds and methods of use | AMGEN INC. | 2006-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060069110-A1 | Substituted heterocyclic compounds and methods of use | MAPT, MYLK2, IAPP | CYP1A2 1159/4885CYP3A4 1290/4885SMN1; SMN2 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.