Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT1 | Q99873 | 3/20 | 0.56 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.56 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | BLM | P54132 | 3/20 | 0.50 |
| ▸ | APP | P05067 | 7/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | APAF1 | O14727 | 1/20 | 0.49 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.49 |
| ▸ | ALPL | P05186 | 1/20 | 0.49 |
| ▸ | ITGAM | P11215 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3936598 | 0.99 | PRMT1 (0.57) | PRMT1PRMT5CARM1MEN1KMT2A | |
| SCHEMBL3936603 | 0.99 | PRMT1 (0.57) | PRMT1PRMT5CARM1MEN1KMT2A | |
| Bromide SCHEMBL5918846 | 0.93 | PRMT1 (0.61) | PRMT1PRMT5CARM1MEN1KMT2A | |
| SCHEMBL3934136 | 0.92 | PRMT1 (0.61) | PRMT1PRMT5CARM1MEN1KMT2A | |
| SCHEMBL3934135 | 0.92 | PRMT1 (0.61) | PRMT1PRMT5CARM1MEN1KMT2A | |
| Iodide SCHEMBL7546369 | 0.86 | APP (0.66) | PRMT1PRMT5CARM1MEN1KMT2A | |
| Bromide SCHEMBL6196061 | 0.82 | PRMT5 (0.47) | PRMT1PRMT5CARM1MEN1KMT2A | |
| Bromide SCHEMBL5918709 | 0.79 | MEN1 (0.57) | PRMT1PRMT5CARM1MEN1KMT2A | |
| Bromide SCHEMBL5918611 | 0.78 | MEN1 (0.49) | PRMT1PRMT5CARM1MEN1KMT2A | |
| SCHEMBL3939557 | 0.78 | MEN1 (0.58) | PRMT1PRMT5CARM1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060162098-A1 | Use of polycationic compounds for dyeing keratin fibres | L'OREAL S.A. (FR) | 2006-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060162098-A1 | Use of polycationic compounds for dyeing keratin fibres | KRT18, DSG1, DSP | PRMT1 1516/4885PRMT5 864/4885CARM1 2037/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.