Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 11/20 | 0.67 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.67 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.43 |
| ▸ | ABL2 | P42684 | 1/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.43 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2050975 | 0.85 | TGFBR1 (0.71) | TGFBR1MAPK14THRBTGFBR2ABL2 | |
| SCHEMBL5091553 | 0.85 | TGFBR1 (0.71) | TGFBR1MAPK14THRBTGFBR2ABL2 | |
| SCHEMBL5188286 | 0.84 | TGFBR1 (0.70) | TGFBR1MAPK14THRBTGFBR2ABL2 | |
| SCHEMBL5186629 | 0.81 | TGFBR1 (0.69) | TGFBR1MAPK14THRBTGFBR2ABL2 | |
| SCHEMBL5186668 | 0.81 | TGFBR1 (0.66) | TGFBR1MAPK14THRBTGFBR2ABL2 | |
| SCHEMBL2045365 | 0.81 | TGFBR1 (0.76) | TGFBR1MAPK14THRBTGFBR2ABL2 | |
| SCHEMBL373455 | 0.81 | TGFBR1 (1.00) | TGFBR1MAPK14THRBTGFBR2ABL2 | |
| SCHEMBL2679359 | 0.81 | TGFBR1 (0.65) | TGFBR1MAPK14THRBTGFBR2ABL2 | |
| SCHEMBL2045872 | 0.81 | TGFBR1 (0.68) | TGFBR1MAPK14THRBTGFBR2ABL2 | |
| SCHEMBL5200821 | 0.81 | TGFBR1 (0.65) | TGFBR1MAPK14THRBTGFBR2BMP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264440-A1 | Pyrazoles and methods of making and using the same | BIOGEN IDEC MA INC. (US) | 2006-11-23 | — | — | US | disclosed |
| EP-1596656-A4 | PYRAZOLES AND METHODS OF MAKING AND USING THE SAME | BIOGEN IDEC INC (US) | 2006-10-18 | — | — | EP | disclosed |
| EP-1596656-A2 | PYRAZOLES AND METHODS OF MAKING AND USING THE SAME | Biogen Idec MA Inc. (US) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004072033-A2 | PYRAZOLES AND METHODS OF MAKING AND USING THE SAME | BIOGEN IDEC MA INC. (US) | 2004-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264440-A1 | Pyrazoles and methods of making and using the same | ALK, ACVR1, ALKBH5 | TGFBR1 26/4885MAPK14 1842/4885THRB 2709/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.