Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.85 |
| ▸ | PDE1A | P54750 | 8/20 | 0.85 |
| ▸ | PDE1B | Q01064 | 8/20 | 0.85 |
| ▸ | PDE1C | Q14123 | 8/20 | 0.85 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.85 |
| ▸ | PDE6A | P16499 | 3/20 | 0.84 |
| ▸ | PDE2A | O00408 | 2/20 | 0.84 |
| ▸ | PDE6D | O43924 | 2/20 | 0.84 |
| ▸ | PDE9A | O76083 | 2/20 | 0.84 |
| ▸ | PDE6G | P18545 | 2/20 | 0.84 |
| ▸ | PDE4A | P27815 | 2/20 | 0.84 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.84 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.84 |
| ▸ | PDE6B | P35913 | 2/20 | 0.84 |
| ▸ | PDE6C | P51160 | 2/20 | 0.84 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.84 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.84 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.84 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.84 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30595263 | 1.00 | PDE5A (0.85) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL24430082 | 0.94 | PDE5A (0.88) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL12922557 | 0.93 | PDE5A (0.84) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL12922554 | 0.93 | PDE5A (0.86) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL5537 | 0.92 | PDE5A (1.00) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL5932069 | 0.91 | PDE5A (0.79) | PDE5APDE1APDE1BPDE1CPDE4B | |
| Vardenafil SCHEMBL5772 | 0.91 | PDE5A (1.00) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL8259092 | 0.91 | PDE5A (0.84) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL14752434 | 0.91 | PDE5A (0.87) | PDE5APDE1APDE1BPDE1CPDE4B | |
| Vardenafil SCHEMBL29390262 | 0.91 | PDE5A (1.00) | PDE5APDE1APDE1BPDE1CPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9969744-B2 | Compounds for use in cognition improvement | FUNDACIÓN LA INVESTIGACIÓN MÉDICA APLICADA (ES) | 2018-05-15 | — | — | US | disclosed |
| US-20170217973-A1 | NOVEL COMPOUNDS FOR USE IN COGNITION IMPROVEMENT | FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA (ES) | 2017-08-03 | — | — | US | disclosed |
| EP-2961741-B1 | NOVEL COMPOUNDS AS DUAL INHIBITORS OF PHOSPHODIESTERASES AND HISTONE DEACETYLASES | FUND PARA LA INVESTIG MEDICA APLICADA (ES) | 2017-04-05 | — | — | EP | disclosed |
| US-20130059844-A1 | 2-PHENYL SUBSTITUTED IMIDAZOTRIAZINONES AS PHOSPHODIESTERASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2013-03-07 | — | — | US | disclosed |
| US-20070299088-A1 | Novel Uses of 2-Phenyl-Substituted Imidazotriazinone Derivatives | BAYER HEALTHCARE AG (DE) | 2007-12-27 | — | — | US | disclosed |
| US-20060160810-A1 | 2-Alkoxyphenyl substituted imidazotriazinones | BAYER AKTIENGESELLSCHAFT (DE) | 2006-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299088-A1 | Novel Uses of 2-Phenyl-Substituted Imidazotriazinone Derivatives | PDE5A, PDE2A, PDE3B | PDE5A 1/4885PDE1A 11/4885PDE1B 13/4885 |
| US-20170217973-A1 | NOVEL COMPOUNDS FOR USE IN COGNITION IMPROVEMENT | CHAT, NLN, GRIN2C | PDE5A 1677/4885PDE1A 831/4885PDE1B 1284/4885 |
| US-20130059844-A1 | 2-PHENYL SUBSTITUTED IMIDAZOTRIAZINONES AS PHOSPHODIESTERASE INHIBITORS | PDE3B, PDE3A, PDE2A | PDE5A 4/4885PDE1A 25/4885PDE1B 14/4885 |
| US-20060160810-A1 | 2-Alkoxyphenyl substituted imidazotriazinones | PDE3B, PDE3A, PDE2A | PDE5A 4/4885PDE1A 33/4885PDE1B 24/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.