Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.59 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.59 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | HPGDS | O60760 | 1/20 | 0.56 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.56 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.53 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.51 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.51 |
| ▸ | LDHA | P00338 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5934141 | 0.87 | HPGDS (0.54) | PTPN1NPC1HPGDSTRPV1PTPN6 | |
| SCHEMBL5934458 | 0.85 | ABCG2 (0.53) | NPC1RAB9ATP53SMN1; SMN2HPGDS | |
| SCHEMBL5934158 | 0.85 | TRPV1 (0.52) | NPC1RAB9ASMN1; SMN2TRPV1P4HTM | |
| SCHEMBL1543044 | 0.84 | PTPN1 (0.70) | PTPN1PTPN2BAZ2BNPC1RAB9A | |
| SCHEMBL5934221 | 0.84 | TRPV1 (0.51) | NPC1RAB9ATRPV1P4HTMABCG2 | |
| SCHEMBL5934149 | 0.84 | TRPV1 (0.51) | NPC1RAB9ASMN1; SMN2TRPV1P4HTM | |
| SCHEMBL5934144 | 0.83 | TRPV1 (0.50) | NPC1RAB9ASMN1; SMN2TRPV1P4HTM | |
| SCHEMBL5934195 | 0.82 | TRPV1 (0.52) | NPC1RAB9ATRPV1P4HTMALDH1A1 | |
| SCHEMBL12136753 | 0.82 | SMN1; SMN2 (0.63) | PTPN1PTPN2NPC1RAB9ATP53 | |
| SCHEMBL16496203 | 0.81 | PTPN1 (0.77) | PTPN1PTPN2BAZ2BNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060100245-A1 | Substituted biphenyl-4-carboxylic acid arylamide analogues | NEUROGEN CORPORATION (US) | 2006-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100245-A1 | Substituted biphenyl-4-carboxylic acid arylamide analogues | HCAR2, AHR, HCAR3 | PTPN1 2912/4885PTPN2 2456/4885BAZ2B 1168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.