Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ESRRB | O95718 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14401989 | 1.00 | KMT2A (0.51) | KMT2ATSHRPTGS1PTGS2GAA | |
| Hydrochloric Acid SCHEMBL4969339 | 0.98 | KMT2A (0.50) | KMT2ATSHRPTGS1PTGS2GAA | |
| Hydrochloric Acid SCHEMBL4969343 | 0.98 | KMT2A (0.50) | KMT2ATSHRPTGS1PTGS2GAA | |
| SCHEMBL6366722 | 0.90 | SLC1A5 (0.49) | KMT2AL3MBTL1ALDH1A1CYP3A4LMNA | |
| Hydrochloric Acid SCHEMBL6366717 | 0.88 | SLC1A5 (0.48) | KMT2AL3MBTL1ALDH1A1CYP3A4LMNA | |
| SCHEMBL28497919 | 0.87 | PARP10 (0.53) | ALDH1A1PGR | |
| SCHEMBL19763136 | 0.81 | CA1 (0.53) | ALDH1A1CES2LMNACES1HTT | |
| SCHEMBL28629458 | 0.81 | CYP1A2 (0.44) | TSHRPTGS2GAAALDH1A1CYP3A4 | |
| SCHEMBL14691129 | 0.81 | NPC1 (0.44) | KMT2ATSHRGAAALDH1A1CES2 | |
| SCHEMBL1221367 | 0.81 | MEN1 (0.56) | KMT2ATSHRGAATDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180125848-A1 | PREPARATION AND METHODS OF USE FOR ORTHO-ARYL 5-MEMBERED HETEROARYL-CARBOXAMIDE CONTAINING MULTI-TARGETED KINASE INHIBITORS | VIBLIOME THERAPEUTICS, LLC | 2018-05-10 | — | — | US | disclosed |
| US-9833455-B2 | Preparation and methods of use for ortho-aryl 5-membered heteroaryl-carboxamide containing multi-targeted kinase inhibitors | SPACEFILL ENTERPRISES LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9828368-B2 | Oxazole orexin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2017-11-28 | — | — | US | disclosed |
| US-20160176858-A1 | OXAZOLE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | US | disclosed |
| EP-1840116-B1 | PROCESS FOR PRODUCING OPTICALLY ACTIVE BETA-HYDROXY-ALPHA-AMINOCARBOXYLIC ACID DERIVATIVE | NISSAN CHEMICAL IND LTD (JP) | 2012-10-03 | — | — | EP | disclosed |
| US-7799941-B2 | Process for producing optically active β-hydroxy-α-aminocarboxylic acid derivative | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2010-09-21 | — | — | US | disclosed |
| US-7799941-B2 | Process for producing optically active β-hydroxy-α-aminocarboxylic acid derivative | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2010-09-21 | — | — | US | disclosed |
| US-7781609-B2 | Process for producing optically active β-hydroxy-α-aminocarboxylic acid derivative | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2010-08-24 | — | — | US | disclosed |
| US-7781609-B2 | Process for producing optically active β-hydroxy-α-aminocarboxylic acid derivative | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2010-08-24 | — | — | US | disclosed |
| US-20080139825-A1 | Process For Producing Optically Active Beta-Hydroxy-Alpha-Aminocarboxylic Acid Derivative | NISSAN CHEMICAL INDUSTRIAL, LTD. (JP) | 2008-06-12 | — | — | US | disclosed |
| US-20080139825-A1 | Process For Producing Optically Active Beta-Hydroxy-Alpha-Aminocarboxylic Acid Derivative | NISSAN CHEMICAL INDUSTRIAL, LTD. (JP) | 2008-06-12 | — | — | US | disclosed |
| US-20060160894-A1 | Benzamides as ppar modulators | LABORATORIOS S.A.L.V.A.T.,S.A. (ES) | 2006-07-20 | — | — | US | disclosed |
| CN-1225471-C | Compounds with growth hormone releasing properties | NOVO NORDISK AS (DK) | 2005-11-02 | — | — | CN | disclosed |
| US-6890939-B2 | Aminopyrrolidine sulfonamides as serine protease inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| US-6710061-B2 | SELECTIVE SERINE PROTEASE OR DUAL-SERINE PROTEASE INHIBITORS OF FACTOR XA AND TRYPTASE | ORTHO-MCNEIL PHARAMCEUTICAL, INC. | 2004-03-23 | — | — | US | disclosed |
| US-6630505-B2 | Inhibitors of Factor Xa and tryptase useful for treating serine protease or dual-serine protease mediated disorders such as thrombotic disorders | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-10-07 | — | — | US | disclosed |
| CN-1176645-A | Compounds with growth hormone releasing properties | NOVO NORDISK AS (DK) | 1998-03-18 | — | — | CN | disclosed |
| US-5378803-A | Analgesics, substance P antagonists, peptides containing thiazole, oxazole or imidazole ring and indole ring | STERLING WINTHROP INC. (US) | 1995-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180125848-A1 | PREPARATION AND METHODS OF USE FOR ORTHO-ARYL 5-MEMBERED HETEROARYL-CARBOXAMIDE CONTAINING MULTI-TARGETED KINASE INHIBITORS | ABL1, ERBB2, MAP3K2 | KMT2A 720/4885TSHR 1513/4885PTGS1 4293/4885 |
| US-20080139825-A1 | Process For Producing Optically Active Beta-Hydroxy-Alpha-Aminocarboxylic Acid Derivative | HCAR2, HCAR1, ALDH7A1 | KMT2A 2426/4885TSHR 2115/4885PTGS1 693/4885 |
| US-20060160894-A1 | Benzamides as ppar modulators | PPARD, PPARA, PPARG | KMT2A 1515/4885TSHR 240/4885PTGS1 588/4885 |
| US-20160176858-A1 | OXAZOLE OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, OXTR | KMT2A 1717/4885TSHR 284/4885PTGS1 1990/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.