Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 9/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.66 |
| ▸ | POLB | P06746 | 7/20 | 0.62 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.62 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.62 |
| ▸ | TNF | P01375 | 1/20 | 0.62 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.62 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.62 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.61 |
| ▸ | BRD4 | O60885 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | LDHA | P00338 | 1/20 | 0.58 |
| ▸ | LDHB | P07195 | 1/20 | 0.58 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.55 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5937449 | 0.92 | BRD4 (0.62) | MEN1KMT2APOLBPLA2G1BATG4B | |
| SCHEMBL5937419 | 0.84 | MEN1 (0.64) | MEN1KMT2APOLBPLA2G1BATG4B | |
| SCHEMBL16775308 | 0.83 | ACMSD (0.81) | MEN1KMT2APOLBPLA2G1BATG4B | |
| SCHEMBL16775367 | 0.83 | MEN1 (0.92) | MEN1KMT2APOLBPLA2G1BATG4B | |
| SCHEMBL5937474 | 0.82 | LDHA (0.62) | MEN1KMT2APOLBPLA2G1BATG4B | |
| SCHEMBL20099427 | 0.82 | MEN1 (0.78) | MEN1KMT2APOLBPLA2G1BATG4B | |
| SCHEMBL6215257 | 0.82 | HPGD (0.73) | MEN1KMT2APOLBPLA2G1BATG4B | |
| SCHEMBL29554397 | 0.81 | BRD4 (0.83) | MEN1KMT2APOLBTNFNOD2 | |
| SCHEMBL29272643 | 0.81 | BRD4 (0.83) | MEN1KMT2APOLBTNFNOD2 | |
| SCHEMBL16772515 | 0.81 | MEN1 (0.80) | MEN1KMT2APOLBPLA2G1BATG4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060100226-A1 | 2-Thiopyrimidinones as therapeutic agents | ATHEROGENICS, INC. | 2006-05-11 | — | — | US | disclosed |
| WO-2006031806-A2 | 2-THIOPYRIMIDINONES AS THERAPEUTIC AGENTS | ATHEROGENICS, INC. (US) | 2006-03-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100226-A1 | 2-Thiopyrimidinones as therapeutic agents | MAP3K6, MAP3K20, MAP3K7 | MEN1 2714/4885KMT2A 2236/4885POLB 3116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.