Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.69 |
| ▸ | GLA | P06280 | 3/20 | 0.69 |
| ▸ | GAA | P10253 | 3/20 | 0.69 |
| ▸ | HPGD | P15428 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.62 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.62 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.62 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.62 |
| ▸ | RAF1 | P04049 | 4/20 | 0.62 |
| ▸ | GCGR | P47871 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | GFER | P55789 | 1/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL572542 | 0.88 | KDM4E (0.67) | ALOX5KMT2AKDM4EALDH1A1GLA | |
| SCHEMBL2593317 | 0.85 | KDM4E (0.91) | ALOX5KMT2AKDM4EALDH1A1GLA | |
| SCHEMBL20573581 | 0.83 | MAPK13 (0.62) | ALOX5KMT2AKDM4EALDH1A1GLA | |
| SCHEMBL5607119 | 0.83 | KDM4E (0.72) | KMT2AKDM4EALDH1A1GLAGAA | |
| SCHEMBL4553424 | 0.82 | ALOX5 (1.00) | ALOX5KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL4552086 | 0.82 | RAF1 (0.88) | ALOX5KMT2AKDM4EALDH1A1GLA | |
| SCHEMBL12561695 | 0.82 | KDM4E (0.80) | ALOX5KMT2AKDM4EALDH1A1GLA | |
| Hydrochloric Acid SCHEMBL19816007 | 0.82 | KDM4E (0.71) | KMT2AKDM4EALDH1A1GLAGAA | |
| Methane SCHEMBL3278320 | 0.82 | MAPK13 (0.79) | ALOX5KMT2AKDM4EALDH1A1GLA | |
| SCHEMBL5074753 | 0.82 | MAPK13 (0.83) | ALOX5KMT2AKDM4EALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060058553-A1 | Novel bicyclic hydroxamates as inhibitors of histone deacetylase | AXYS PHARMACEUTICALS, INC. (US) | 2006-03-16 | — | — | US | disclosed |
| EP-1472216-A2 | NOVEL BICYCLIC HYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | Axys Pharmaceuticals (US) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003066579-A2 | NOVEL BICYCLIC HYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | AXYS PHARMACEUTICALS (US) | 2003-08-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060058553-A1 | Novel bicyclic hydroxamates as inhibitors of histone deacetylase | HDAC1, HDAC2, HDAC11 | ALOX5 4002/4885KMT2A 100/4885KDM4E 418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.