Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 8/20 | 0.54 |
| ▸ | BCHE | P06276 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.45 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.45 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.45 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.45 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.45 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.45 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.45 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.45 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | FABP1 | P07148 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27961249 | 0.94 | ACHE (0.59) | ACHEBCHEKDM4ECACNB4CACNA1A | |
| SCHEMBL4879677 | 0.94 | ACHE (0.59) | ACHEBCHEKDM4ECACNB4CACNA1A | |
| SCHEMBL27961346 | 0.94 | ACHE (0.59) | ACHEBCHEKDM4ECACNB4CACNA1A | |
| SCHEMBL27961311 | 0.92 | ACHE (0.56) | ACHEBCHEKDM4ECACNB4CACNA1A | |
| SCHEMBL27961247 | 0.92 | ACHE (0.56) | ACHEBCHEKDM4ECACNB4CACNA1A | |
| SCHEMBL5487150 | 0.90 | ACHE (0.55) | ACHEBCHEKDM4ECACNB4CACNA1A | |
| SCHEMBL28449689 | 0.86 | ACHE (0.56) | ACHEBCHEKDM4ECACNB4CACNA1A | |
| SCHEMBL31139216 | 0.86 | ACHE (0.56) | ACHEBCHEKDM4ECACNB4CACNA1A | |
| SCHEMBL22470555 | 0.85 | BCHE (0.50) | ACHEBCHEKDM4ECACNB4CACNA1A | |
| SCHEMBL31139207 | 0.84 | ACHE (0.56) | ACHEBCHEKDM4ECACNB4CACNA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558255-B1 | DUAL BINDING SITE ACETYLCHOLINESTERASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | NEUROPHARMA SA (ES) | 2006-12-27 | — | — | EP | disclosed |
| US-20060142323-A1 | Dual binding site acetylcholinesterase inhibitors for the treatment of alzheimer's disease | NEUROPHARMA, S.A. (ES) | 2006-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142323-A1 | Dual binding site acetylcholinesterase inhibitors for the treatment of alzheimer's disease | ACHE, PSEN2, CHAT | OPRM1 1966/4885ACHE 1/4885BCHE 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.